Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage

• Main Authors: Qian-Qian Li, Lan-Jun Li, Xin-Yu Wang, Yu-Ying Sun, Jun Wu
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2018-08-01
• Series: Frontiers in Neurology
• Subjects: heme oxygenase-1; intracerebral hemorrhage; heat shock protein 32; heme; neurological impairment; microglia
• Online Access: https://www.frontiersin.org/article/10.3389/fneur.2018.00682/full
• ISSN: 1664-2295

Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage. Heme oxygenase is the initial and rate-limiting enzyme of heme catabolism, and the expression of heme oxygenase-1 (HO-1) is rapidly induced following acute brain injury. As HO-1 exerts it effects via various metabolites, its role during ICH remains complex. Therefore, in-depth studies regarding the role of HO-1 in secondary brain damage following ICH may provide a theoretical basis for neuroprotective function after ICH. The present review aims to summarize recent key studies regarding the effects of HO-1 following ICH, as well as its influence on ICH prognosis.