A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique

Deep brain stimulation is a clinical technique for the treatment of parkinson’s disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating si...

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Main Authors:	A. Paffi, F. Apollonio, M. G. Puxeddu, M. Parazzini, G. d’Inzeo, P. Ravazzani, M. Liberti
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2013/262739

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spelling	doaj-81c8e5358be64af59e86c2d250565d912020-11-24T22:42:47ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/262739262739A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS TechniqueA. Paffi0F. Apollonio1M. G. Puxeddu2M. Parazzini3G. d’Inzeo4P. Ravazzani5M. Liberti6Department of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyItalian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyItalian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, ItalyDepartment of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, ItalyDeep brain stimulation is a clinical technique for the treatment of parkinson’s disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.http://dx.doi.org/10.1155/2013/262739
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	A. Paffi F. Apollonio M. G. Puxeddu M. Parazzini G. d’Inzeo P. Ravazzani M. Liberti
spellingShingle	A. Paffi F. Apollonio M. G. Puxeddu M. Parazzini G. d’Inzeo P. Ravazzani M. Liberti A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique BioMed Research International
author_facet	A. Paffi F. Apollonio M. G. Puxeddu M. Parazzini G. d’Inzeo P. Ravazzani M. Liberti
author_sort	A. Paffi
title	A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_short	A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_full	A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_fullStr	A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_full_unstemmed	A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique
title_sort	numerical study to compare stimulations by intraoperative microelectrodes and chronic macroelectrodes in the dbs technique
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2013-01-01
description	Deep brain stimulation is a clinical technique for the treatment of parkinson’s disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.
url	http://dx.doi.org/10.1155/2013/262739
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A Numerical Study to Compare Stimulations by Intraoperative Microelectrodes and Chronic Macroelectrodes in the DBS Technique

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