Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcripti...

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Main Authors:	Amit Grover, Alejandra Sanjuan-Pla, Supat Thongjuea, Joana Carrelha, Alice Giustacchini, Adriana Gambardella, Iain Macaulay, Elena Mancini, Tiago C. Luis, Adam Mead, Sten Eirik W. Jacobsen, Claus Nerlov
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11075

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spelling	doaj-81c978c8b4c243cab74583942727f9f72021-05-11T10:36:12ZengNature Publishing GroupNature Communications2041-17232016-03-017111210.1038/ncomms11075Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cellsAmit Grover0Alejandra Sanjuan-Pla1Supat Thongjuea2Joana Carrelha3Alice Giustacchini4Adriana Gambardella5Iain Macaulay6Elena Mancini7Tiago C. Luis8Adam Mead9Sten Eirik W. Jacobsen10Claus Nerlov11MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordEMBL Mouse Biology ProgramMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordMRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordWith age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.https://doi.org/10.1038/ncomms11075
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Amit Grover Alejandra Sanjuan-Pla Supat Thongjuea Joana Carrelha Alice Giustacchini Adriana Gambardella Iain Macaulay Elena Mancini Tiago C. Luis Adam Mead Sten Eirik W. Jacobsen Claus Nerlov
spellingShingle	Amit Grover Alejandra Sanjuan-Pla Supat Thongjuea Joana Carrelha Alice Giustacchini Adriana Gambardella Iain Macaulay Elena Mancini Tiago C. Luis Adam Mead Sten Eirik W. Jacobsen Claus Nerlov Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells Nature Communications
author_facet	Amit Grover Alejandra Sanjuan-Pla Supat Thongjuea Joana Carrelha Alice Giustacchini Adriana Gambardella Iain Macaulay Elena Mancini Tiago C. Luis Adam Mead Sten Eirik W. Jacobsen Claus Nerlov
author_sort	Amit Grover
title	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_short	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_full	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_fullStr	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_full_unstemmed	Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
title_sort	single-cell rna sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-03-01
description	With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.
url	https://doi.org/10.1038/ncomms11075
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Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

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