Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated wit...

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Main Authors: Giuseppe Bersani, Pietropaolo Marino, Giuseppe Valeriani, Valentina Cuoco, Claudia Zitelli, Claudia Melcore, Francesco Saverio Bersani
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Psychiatry
Online Access:http://dx.doi.org/10.1155/2013/926395
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spelling doaj-81caf6560819419aba62966bb2ab4d752020-11-24T23:14:51ZengHindawi LimitedCase Reports in Psychiatry2090-682X2090-68382013-01-01201310.1155/2013/926395926395Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney TransplantGiuseppe Bersani0Pietropaolo Marino1Giuseppe Valeriani2Valentina Cuoco3Claudia Zitelli4Claudia Melcore5Francesco Saverio Bersani6Department of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, UOD Fiorini Hospital, Sapienza University of Rome, Viale dell'Universitá No. 30, 00185 Rome, ItalySeveral neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.http://dx.doi.org/10.1155/2013/926395
collection DOAJ
language English
format Article
sources DOAJ
author Giuseppe Bersani
Pietropaolo Marino
Giuseppe Valeriani
Valentina Cuoco
Claudia Zitelli
Claudia Melcore
Francesco Saverio Bersani
spellingShingle Giuseppe Bersani
Pietropaolo Marino
Giuseppe Valeriani
Valentina Cuoco
Claudia Zitelli
Claudia Melcore
Francesco Saverio Bersani
Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
Case Reports in Psychiatry
author_facet Giuseppe Bersani
Pietropaolo Marino
Giuseppe Valeriani
Valentina Cuoco
Claudia Zitelli
Claudia Melcore
Francesco Saverio Bersani
author_sort Giuseppe Bersani
title Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_short Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_full Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_fullStr Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_full_unstemmed Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
title_sort manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant
publisher Hindawi Limited
series Case Reports in Psychiatry
issn 2090-682X
2090-6838
publishDate 2013-01-01
description Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.
url http://dx.doi.org/10.1155/2013/926395
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