Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic...

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Main Authors: Weiguo Zhang, Jian-Hua Mao, Wei Zhu, Anshu K. Jain, Ke Liu, James B. Brown, Gary H. Karpen
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12619
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spelling doaj-81d5d64089a14736a7f1215807ef737a2021-05-11T10:45:48ZengNature Publishing GroupNature Communications2041-17232016-08-017111510.1038/ncomms12619Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapyWeiguo Zhang0Jian-Hua Mao1Wei Zhu2Anshu K. Jain3Ke Liu4James B. Brown5Gary H. Karpen6Biological Systems and Engineering Division, Lawrence Berkeley National LaboratoryBiological Systems and Engineering Division, Lawrence Berkeley National LaboratoryDepartment of Translational Bioinformatics, Cellular Biomedicine Group, Inc.Department of Therapeutic Radiology, Yale School of Medicine, Yale UniversityEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National LaboratoryEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National LaboratoryBiological Systems and Engineering Division, Lawrence Berkeley National LaboratoryCentromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic therapies.https://doi.org/10.1038/ncomms12619
collection DOAJ
language English
format Article
sources DOAJ
author Weiguo Zhang
Jian-Hua Mao
Wei Zhu
Anshu K. Jain
Ke Liu
James B. Brown
Gary H. Karpen
spellingShingle Weiguo Zhang
Jian-Hua Mao
Wei Zhu
Anshu K. Jain
Ke Liu
James B. Brown
Gary H. Karpen
Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
Nature Communications
author_facet Weiguo Zhang
Jian-Hua Mao
Wei Zhu
Anshu K. Jain
Ke Liu
James B. Brown
Gary H. Karpen
author_sort Weiguo Zhang
title Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_short Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_full Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_fullStr Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_full_unstemmed Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
title_sort centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-08-01
description Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic therapies.
url https://doi.org/10.1038/ncomms12619
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AT weizhu centromereandkinetochoregenemisexpressionpredictscancerpatientsurvivalandresponsetoradiotherapyandchemotherapy
AT anshukjain centromereandkinetochoregenemisexpressionpredictscancerpatientsurvivalandresponsetoradiotherapyandchemotherapy
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AT jamesbbrown centromereandkinetochoregenemisexpressionpredictscancerpatientsurvivalandresponsetoradiotherapyandchemotherapy
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