The Role of Secretory Pathways in <i>Candida albicans</i> Pathogenesis
<i>Candida albicans </i>is a fungus that is a commensal organism and a member of the normal human microbiota. It has the ability to transition into an opportunistic invasive pathogen. Attributes that support pathogenesis include secretion of virulence-associated proteins, hyphal formatio...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-02-01
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Series: | Journal of Fungi |
Subjects: | |
Online Access: | https://www.mdpi.com/2309-608X/6/1/26 |
Summary: | <i>Candida albicans </i>is a fungus that is a commensal organism and a member of the normal human microbiota. It has the ability to transition into an opportunistic invasive pathogen. Attributes that support pathogenesis include secretion of virulence-associated proteins, hyphal formation, and biofilm formation. These processes are supported by secretion, as defined in the broad context of membrane trafficking. In this review, we examine the role of secretory pathways in <i>Candida</i> virulence, with a focus on the model opportunistic fungal pathogen, <i>Candida albicans</i>. |
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ISSN: | 2309-608X |