Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields
Three-dimensional protein molecule structures are essential for acquiring a deeper insight of the human genome, and for developing novel protein-based pharmaceuticals. X-ray diffraction studies of such structures require well-diffracting protein crystals. A set of external physical factors may promo...
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doaj-81e6f20e51fd4fa4a4be4b319fa2960e2020-11-24T21:09:58ZengMDPI AGCrystals2073-43522017-10-0171031010.3390/cryst7100310cryst7100310Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric FieldsChristo N. Nanev0Rostislaw Kaischew Institute of Physical Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaThree-dimensional protein molecule structures are essential for acquiring a deeper insight of the human genome, and for developing novel protein-based pharmaceuticals. X-ray diffraction studies of such structures require well-diffracting protein crystals. A set of external physical factors may promote and direct protein crystallization so that crystals obtained are useful for X-ray studies. Application of electric fields aids control over protein crystal size and diffraction quality. Protein crystal nucleation and growth in the presence of electric fields are reviewed. A notion of mesoscopic level of impact on the protein crystallization exercised by an electric field is also considered.https://www.mdpi.com/2073-4352/7/10/310protein crystallizationclassical and two-step nucleation mechanismsimpact of electric fields on the protein crystallizationexternal and internal electric fieldsnumber densitysize and quality of protein crystals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christo N. Nanev |
spellingShingle |
Christo N. Nanev Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields Crystals protein crystallization classical and two-step nucleation mechanisms impact of electric fields on the protein crystallization external and internal electric fields number density size and quality of protein crystals |
author_facet |
Christo N. Nanev |
author_sort |
Christo N. Nanev |
title |
Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields |
title_short |
Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields |
title_full |
Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields |
title_fullStr |
Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields |
title_full_unstemmed |
Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields |
title_sort |
recent insights into the crystallization process; protein crystal nucleation and growth peculiarities; processes in the presence of electric fields |
publisher |
MDPI AG |
series |
Crystals |
issn |
2073-4352 |
publishDate |
2017-10-01 |
description |
Three-dimensional protein molecule structures are essential for acquiring a deeper insight of the human genome, and for developing novel protein-based pharmaceuticals. X-ray diffraction studies of such structures require well-diffracting protein crystals. A set of external physical factors may promote and direct protein crystallization so that crystals obtained are useful for X-ray studies. Application of electric fields aids control over protein crystal size and diffraction quality. Protein crystal nucleation and growth in the presence of electric fields are reviewed. A notion of mesoscopic level of impact on the protein crystallization exercised by an electric field is also considered. |
topic |
protein crystallization classical and two-step nucleation mechanisms impact of electric fields on the protein crystallization external and internal electric fields number density size and quality of protein crystals |
url |
https://www.mdpi.com/2073-4352/7/10/310 |
work_keys_str_mv |
AT christonnanev recentinsightsintothecrystallizationprocessproteincrystalnucleationandgrowthpeculiaritiesprocessesinthepresenceofelectricfields |
_version_ |
1716756782605402112 |