Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields

Three-dimensional protein molecule structures are essential for acquiring a deeper insight of the human genome, and for developing novel protein-based pharmaceuticals. X-ray diffraction studies of such structures require well-diffracting protein crystals. A set of external physical factors may promo...

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Main Author:	Christo N. Nanev
Format:	Article
Language:	English
Published:	MDPI AG 2017-10-01
Series:	Crystals
Subjects:	protein crystallization classical and two-step nucleation mechanisms impact of electric fields on the protein crystallization external and internal electric fields number density size and quality of protein crystals
Online Access:	https://www.mdpi.com/2073-4352/7/10/310

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record_format	Article
spelling	doaj-81e6f20e51fd4fa4a4be4b319fa2960e2020-11-24T21:09:58ZengMDPI AGCrystals2073-43522017-10-0171031010.3390/cryst7100310cryst7100310Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric FieldsChristo N. Nanev0Rostislaw Kaischew Institute of Physical Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaThree-dimensional protein molecule structures are essential for acquiring a deeper insight of the human genome, and for developing novel protein-based pharmaceuticals. X-ray diffraction studies of such structures require well-diffracting protein crystals. A set of external physical factors may promote and direct protein crystallization so that crystals obtained are useful for X-ray studies. Application of electric fields aids control over protein crystal size and diffraction quality. Protein crystal nucleation and growth in the presence of electric fields are reviewed. A notion of mesoscopic level of impact on the protein crystallization exercised by an electric field is also considered.https://www.mdpi.com/2073-4352/7/10/310protein crystallizationclassical and two-step nucleation mechanismsimpact of electric fields on the protein crystallizationexternal and internal electric fieldsnumber densitysize and quality of protein crystals
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christo N. Nanev
spellingShingle	Christo N. Nanev Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields Crystals protein crystallization classical and two-step nucleation mechanisms impact of electric fields on the protein crystallization external and internal electric fields number density size and quality of protein crystals
author_facet	Christo N. Nanev
author_sort	Christo N. Nanev
title	Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields
title_short	Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields
title_full	Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields
title_fullStr	Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields
title_full_unstemmed	Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields
title_sort	recent insights into the crystallization process; protein crystal nucleation and growth peculiarities; processes in the presence of electric fields
publisher	MDPI AG
series	Crystals
issn	2073-4352
publishDate	2017-10-01
description	Three-dimensional protein molecule structures are essential for acquiring a deeper insight of the human genome, and for developing novel protein-based pharmaceuticals. X-ray diffraction studies of such structures require well-diffracting protein crystals. A set of external physical factors may promote and direct protein crystallization so that crystals obtained are useful for X-ray studies. Application of electric fields aids control over protein crystal size and diffraction quality. Protein crystal nucleation and growth in the presence of electric fields are reviewed. A notion of mesoscopic level of impact on the protein crystallization exercised by an electric field is also considered.
topic	protein crystallization classical and two-step nucleation mechanisms impact of electric fields on the protein crystallization external and internal electric fields number density size and quality of protein crystals
url	https://www.mdpi.com/2073-4352/7/10/310
work_keys_str_mv	AT christonnanev recentinsightsintothecrystallizationprocessproteincrystalnucleationandgrowthpeculiaritiesprocessesinthepresenceofelectricfields
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Recent Insights into the Crystallization Process; Protein Crystal Nucleation and Growth Peculiarities; Processes in the Presence of Electric Fields

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