The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes
Poor glycaemic control and high blood pressure are two important risk factors for the development of retinopathy and nephropathy in Type 1 diabetes. The renin-angiotensin-aldosterone system (RAAS) may be involved in this process, since treatment with angiotensin-converting enzyme (ACE) inhibitors po...
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Hindawi - SAGE Publishing
2000-12-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.3317/jraas.2000.065 |
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doaj-81ea10de4cb144a0a1becfcfefad0d402021-05-02T19:14:45ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32032000-12-01110.3317/jraas.2000.065The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetesMats BojestigFredrik H NystromHans J ArnqvistJohnny LudvigssonBengt E KarlbergPoor glycaemic control and high blood pressure are two important risk factors for the development of retinopathy and nephropathy in Type 1 diabetes. The renin-angiotensin-aldosterone system (RAAS) may be involved in this process, since treatment with angiotensin-converting enzyme (ACE) inhibitors postpones the development of these complications. We investigated whether plasma renin activity (PRA), plasma angiotensin II (Ang II) and atrial natriuretic peptide (ANP) differed in Type 1 diabetic patients compared with healthy controls. We recruited 80 patients with Type 1 diabetes of more than 10 years' duration and 75 age-matched controls. We found that PRA and Ang II concentrations were significantly lower in patients than in the controls. The levels of ANP, on the other hand, were higher in patients than in controls. PRA correlated negatively to the mean value of HbA 1c during the previous five years. PRA and Ang II were significantly lower in patients with mean HbA 1c >8.4% compared with those with mean HbA 1c <7.2%. In summary, we found patients with Type 1 diabetes to have RAAS suppression and increased ANP levels, suggesting a state of fluid retention.https://doi.org/10.3317/jraas.2000.065 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mats Bojestig Fredrik H Nystrom Hans J Arnqvist Johnny Ludvigsson Bengt E Karlberg |
spellingShingle |
Mats Bojestig Fredrik H Nystrom Hans J Arnqvist Johnny Ludvigsson Bengt E Karlberg The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Mats Bojestig Fredrik H Nystrom Hans J Arnqvist Johnny Ludvigsson Bengt E Karlberg |
author_sort |
Mats Bojestig |
title |
The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes |
title_short |
The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes |
title_full |
The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes |
title_fullStr |
The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes |
title_full_unstemmed |
The renin-angiotensin-aldosterone system is suppressed in adults with Type 1 diabetes |
title_sort |
renin-angiotensin-aldosterone system is suppressed in adults with type 1 diabetes |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 |
publishDate |
2000-12-01 |
description |
Poor glycaemic control and high blood pressure are two important risk factors for the development of retinopathy and nephropathy in Type 1 diabetes. The renin-angiotensin-aldosterone system (RAAS) may be involved in this process, since treatment with angiotensin-converting enzyme (ACE) inhibitors postpones the development of these complications. We investigated whether plasma renin activity (PRA), plasma angiotensin II (Ang II) and atrial natriuretic peptide (ANP) differed in Type 1 diabetic patients compared with healthy controls. We recruited 80 patients with Type 1 diabetes of more than 10 years' duration and 75 age-matched controls. We found that PRA and Ang II concentrations were significantly lower in patients than in the controls. The levels of ANP, on the other hand, were higher in patients than in controls. PRA correlated negatively to the mean value of HbA 1c during the previous five years. PRA and Ang II were significantly lower in patients with mean HbA 1c >8.4% compared with those with mean HbA 1c <7.2%. In summary, we found patients with Type 1 diabetes to have RAAS suppression and increased ANP levels, suggesting a state of fluid retention. |
url |
https://doi.org/10.3317/jraas.2000.065 |
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