Hearing analysis in heterozygous and homozygous klotho gene deficient mice

Objective: To understand the crucial role of the klotho gene in hearing development in mouse models. Methods: PCR was used to identify CBA mice with different genotypes, i.e. WT, heterozygous (klotho +/−) or homozygous (klotho −/−). Mice phenotype and weight were recorded postnatal 25 days (P-25) an...

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Bibliographic Details
Main Authors: Na Yuan, Shiwei Qiu, Qian Wang, Wei Zhuang, Guoping Li, Tiantian Sun, Shiming Yang, Yuehua Qiao, Xi Shi
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Journal of Otology
Online Access:http://www.sciencedirect.com/science/article/pii/S1672293018300102