Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses

Selective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear. Here the authors show that Drosophila Kenny may be an evolution-selected autophagy receptor for the down-regulation of innate NF-κB...

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Main Authors:	Radu Tusco, Anne-Claire Jacomin, Ashish Jain, Bridget S. Penman, Kenneth Bowitz Larsen, Terje Johansen, Ioannis P. Nezis
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01287-9

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spelling	doaj-81ed953ad9ea48a8980dd1e3764b1e042021-05-11T07:24:00ZengNature Publishing GroupNature Communications2041-17232017-11-018111510.1038/s41467-017-01287-9Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responsesRadu Tusco0Anne-Claire Jacomin1Ashish Jain2Bridget S. Penman3Kenneth Bowitz Larsen4Terje Johansen5Ioannis P. Nezis6School of Life Sciences, University of WarwickSchool of Life Sciences, University of WarwickMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø – The Arctic University of NorwaySchool of Life Sciences, University of WarwickMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø – The Arctic University of NorwayMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø – The Arctic University of NorwaySchool of Life Sciences, University of WarwickSelective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear. Here the authors show that Drosophila Kenny may be an evolution-selected autophagy receptor for the down-regulation of innate NF-κB activationhttps://doi.org/10.1038/s41467-017-01287-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Radu Tusco Anne-Claire Jacomin Ashish Jain Bridget S. Penman Kenneth Bowitz Larsen Terje Johansen Ioannis P. Nezis
spellingShingle	Radu Tusco Anne-Claire Jacomin Ashish Jain Bridget S. Penman Kenneth Bowitz Larsen Terje Johansen Ioannis P. Nezis Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses Nature Communications
author_facet	Radu Tusco Anne-Claire Jacomin Ashish Jain Bridget S. Penman Kenneth Bowitz Larsen Terje Johansen Ioannis P. Nezis
author_sort	Radu Tusco
title	Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
title_short	Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
title_full	Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
title_fullStr	Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
title_full_unstemmed	Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses
title_sort	kenny mediates selective autophagic degradation of the ikk complex to control innate immune responses
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	Selective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear. Here the authors show that Drosophila Kenny may be an evolution-selected autophagy receptor for the down-regulation of innate NF-κB activation
url	https://doi.org/10.1038/s41467-017-01287-9
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Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses

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