Evolution of high-level resistance during low-level antibiotic exposure
Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.
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Nature Publishing Group
2018-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04059-1 |
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doaj-81f65f64c61b4ccbb903415fc281cf6f2021-05-11T10:32:24ZengNature Publishing GroupNature Communications2041-17232018-04-019111210.1038/s41467-018-04059-1Evolution of high-level resistance during low-level antibiotic exposureErik Wistrand-Yuen0Michael Knopp1Karin Hjort2Sanna Koskiniemi3Otto G. Berg4Dan I. Andersson5Department of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Cell and Molecular Biology, Uppsala UniversityDepartment of Cell and Molecular Biology, Uppsala UniversityDepartment of Medical Biochemistry and Microbiology, Uppsala UniversityMutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.https://doi.org/10.1038/s41467-018-04059-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson |
spellingShingle |
Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson Evolution of high-level resistance during low-level antibiotic exposure Nature Communications |
author_facet |
Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson |
author_sort |
Erik Wistrand-Yuen |
title |
Evolution of high-level resistance during low-level antibiotic exposure |
title_short |
Evolution of high-level resistance during low-level antibiotic exposure |
title_full |
Evolution of high-level resistance during low-level antibiotic exposure |
title_fullStr |
Evolution of high-level resistance during low-level antibiotic exposure |
title_full_unstemmed |
Evolution of high-level resistance during low-level antibiotic exposure |
title_sort |
evolution of high-level resistance during low-level antibiotic exposure |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-04-01 |
description |
Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin. |
url |
https://doi.org/10.1038/s41467-018-04059-1 |
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