Evolution of high-level resistance during low-level antibiotic exposure

Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.

Bibliographic Details
Main Authors:	Erik Wistrand-Yuen, Michael Knopp, Karin Hjort, Sanna Koskiniemi, Otto G. Berg, Dan I. Andersson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04059-1

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spelling	doaj-81f65f64c61b4ccbb903415fc281cf6f2021-05-11T10:32:24ZengNature Publishing GroupNature Communications2041-17232018-04-019111210.1038/s41467-018-04059-1Evolution of high-level resistance during low-level antibiotic exposureErik Wistrand-Yuen0Michael Knopp1Karin Hjort2Sanna Koskiniemi3Otto G. Berg4Dan I. Andersson5Department of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Medical Biochemistry and Microbiology, Uppsala UniversityDepartment of Cell and Molecular Biology, Uppsala UniversityDepartment of Cell and Molecular Biology, Uppsala UniversityDepartment of Medical Biochemistry and Microbiology, Uppsala UniversityMutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.https://doi.org/10.1038/s41467-018-04059-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson
spellingShingle	Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson Evolution of high-level resistance during low-level antibiotic exposure Nature Communications
author_facet	Erik Wistrand-Yuen Michael Knopp Karin Hjort Sanna Koskiniemi Otto G. Berg Dan I. Andersson
author_sort	Erik Wistrand-Yuen
title	Evolution of high-level resistance during low-level antibiotic exposure
title_short	Evolution of high-level resistance during low-level antibiotic exposure
title_full	Evolution of high-level resistance during low-level antibiotic exposure
title_fullStr	Evolution of high-level resistance during low-level antibiotic exposure
title_full_unstemmed	Evolution of high-level resistance during low-level antibiotic exposure
title_sort	evolution of high-level resistance during low-level antibiotic exposure
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-04-01
description	Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.
url	https://doi.org/10.1038/s41467-018-04059-1
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Evolution of high-level resistance during low-level antibiotic exposure

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