Coordination of dendritic inhibition through local disinhibitory circuits

It has been recognized for some time that different subtypes of cortical inhibitory interneurons innervate specific dendritic domains of principal cells and release GABA at particular times during behaviorally relevant network oscillations. However, the lack of basic information on how the activity...

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Main Authors: Ruggiero eFrancavilla, Xiao eLuo, Elise eMagnin, Leonid eTyan, Lisa eTopolnik
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
VIP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00005/full
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spelling doaj-8201acbc6cd848d4976b0369b7af13762020-11-24T23:02:36ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632015-02-01710.3389/fnsyn.2015.00005128233Coordination of dendritic inhibition through local disinhibitory circuitsRuggiero eFrancavilla0Xiao eLuo1Elise eMagnin2Leonid eTyan3Lisa eTopolnik4Laval UniversityLaval UniversityLaval UniversityLaval UniversityLaval UniversityIt has been recognized for some time that different subtypes of cortical inhibitory interneurons innervate specific dendritic domains of principal cells and release GABA at particular times during behaviorally relevant network oscillations. However, the lack of basic information on how the activity of interneurons can be controlled by GABA released in particular behavioral states has hindered our understanding of the rules that govern the spatio-temporal organization and function of dendritic inhibition. Similar to principal cells, any given interneuron may receive several functionally distinct inhibitory inputs that target its specific subcellular domains. We recently found that local circuitry of the so-called interneuron-specific (IS) interneurons is responsible for dendritic inhibition of different subtypes of hippocampal interneurons with a great impact on cell output. Here, we will review the properties and the specificity of connections of IS interneurons in the CA1 hippocampus and neocortex, and discuss their possible role in the activity-dependent regulation of dendritic inhibition received by pyramidal neurons.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00005/fullGABAinterneuronVIPsynapsedisinhibition
collection DOAJ
language English
format Article
sources DOAJ
author Ruggiero eFrancavilla
Xiao eLuo
Elise eMagnin
Leonid eTyan
Lisa eTopolnik
spellingShingle Ruggiero eFrancavilla
Xiao eLuo
Elise eMagnin
Leonid eTyan
Lisa eTopolnik
Coordination of dendritic inhibition through local disinhibitory circuits
Frontiers in Synaptic Neuroscience
GABA
interneuron
VIP
synapse
disinhibition
author_facet Ruggiero eFrancavilla
Xiao eLuo
Elise eMagnin
Leonid eTyan
Lisa eTopolnik
author_sort Ruggiero eFrancavilla
title Coordination of dendritic inhibition through local disinhibitory circuits
title_short Coordination of dendritic inhibition through local disinhibitory circuits
title_full Coordination of dendritic inhibition through local disinhibitory circuits
title_fullStr Coordination of dendritic inhibition through local disinhibitory circuits
title_full_unstemmed Coordination of dendritic inhibition through local disinhibitory circuits
title_sort coordination of dendritic inhibition through local disinhibitory circuits
publisher Frontiers Media S.A.
series Frontiers in Synaptic Neuroscience
issn 1663-3563
publishDate 2015-02-01
description It has been recognized for some time that different subtypes of cortical inhibitory interneurons innervate specific dendritic domains of principal cells and release GABA at particular times during behaviorally relevant network oscillations. However, the lack of basic information on how the activity of interneurons can be controlled by GABA released in particular behavioral states has hindered our understanding of the rules that govern the spatio-temporal organization and function of dendritic inhibition. Similar to principal cells, any given interneuron may receive several functionally distinct inhibitory inputs that target its specific subcellular domains. We recently found that local circuitry of the so-called interneuron-specific (IS) interneurons is responsible for dendritic inhibition of different subtypes of hippocampal interneurons with a great impact on cell output. Here, we will review the properties and the specificity of connections of IS interneurons in the CA1 hippocampus and neocortex, and discuss their possible role in the activity-dependent regulation of dendritic inhibition received by pyramidal neurons.
topic GABA
interneuron
VIP
synapse
disinhibition
url http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00005/full
work_keys_str_mv AT ruggieroefrancavilla coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits
AT xiaoeluo coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits
AT eliseemagnin coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits
AT leonidetyan coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits
AT lisaetopolnik coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits
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