Coordination of dendritic inhibition through local disinhibitory circuits
It has been recognized for some time that different subtypes of cortical inhibitory interneurons innervate specific dendritic domains of principal cells and release GABA at particular times during behaviorally relevant network oscillations. However, the lack of basic information on how the activity...
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2015-02-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00005/full |
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doaj-8201acbc6cd848d4976b0369b7af13762020-11-24T23:02:36ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632015-02-01710.3389/fnsyn.2015.00005128233Coordination of dendritic inhibition through local disinhibitory circuitsRuggiero eFrancavilla0Xiao eLuo1Elise eMagnin2Leonid eTyan3Lisa eTopolnik4Laval UniversityLaval UniversityLaval UniversityLaval UniversityLaval UniversityIt has been recognized for some time that different subtypes of cortical inhibitory interneurons innervate specific dendritic domains of principal cells and release GABA at particular times during behaviorally relevant network oscillations. However, the lack of basic information on how the activity of interneurons can be controlled by GABA released in particular behavioral states has hindered our understanding of the rules that govern the spatio-temporal organization and function of dendritic inhibition. Similar to principal cells, any given interneuron may receive several functionally distinct inhibitory inputs that target its specific subcellular domains. We recently found that local circuitry of the so-called interneuron-specific (IS) interneurons is responsible for dendritic inhibition of different subtypes of hippocampal interneurons with a great impact on cell output. Here, we will review the properties and the specificity of connections of IS interneurons in the CA1 hippocampus and neocortex, and discuss their possible role in the activity-dependent regulation of dendritic inhibition received by pyramidal neurons.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00005/fullGABAinterneuronVIPsynapsedisinhibition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruggiero eFrancavilla Xiao eLuo Elise eMagnin Leonid eTyan Lisa eTopolnik |
spellingShingle |
Ruggiero eFrancavilla Xiao eLuo Elise eMagnin Leonid eTyan Lisa eTopolnik Coordination of dendritic inhibition through local disinhibitory circuits Frontiers in Synaptic Neuroscience GABA interneuron VIP synapse disinhibition |
author_facet |
Ruggiero eFrancavilla Xiao eLuo Elise eMagnin Leonid eTyan Lisa eTopolnik |
author_sort |
Ruggiero eFrancavilla |
title |
Coordination of dendritic inhibition through local disinhibitory circuits |
title_short |
Coordination of dendritic inhibition through local disinhibitory circuits |
title_full |
Coordination of dendritic inhibition through local disinhibitory circuits |
title_fullStr |
Coordination of dendritic inhibition through local disinhibitory circuits |
title_full_unstemmed |
Coordination of dendritic inhibition through local disinhibitory circuits |
title_sort |
coordination of dendritic inhibition through local disinhibitory circuits |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Synaptic Neuroscience |
issn |
1663-3563 |
publishDate |
2015-02-01 |
description |
It has been recognized for some time that different subtypes of cortical inhibitory interneurons innervate specific dendritic domains of principal cells and release GABA at particular times during behaviorally relevant network oscillations. However, the lack of basic information on how the activity of interneurons can be controlled by GABA released in particular behavioral states has hindered our understanding of the rules that govern the spatio-temporal organization and function of dendritic inhibition. Similar to principal cells, any given interneuron may receive several functionally distinct inhibitory inputs that target its specific subcellular domains. We recently found that local circuitry of the so-called interneuron-specific (IS) interneurons is responsible for dendritic inhibition of different subtypes of hippocampal interneurons with a great impact on cell output. Here, we will review the properties and the specificity of connections of IS interneurons in the CA1 hippocampus and neocortex, and discuss their possible role in the activity-dependent regulation of dendritic inhibition received by pyramidal neurons. |
topic |
GABA interneuron VIP synapse disinhibition |
url |
http://journal.frontiersin.org/Journal/10.3389/fnsyn.2015.00005/full |
work_keys_str_mv |
AT ruggieroefrancavilla coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits AT xiaoeluo coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits AT eliseemagnin coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits AT leonidetyan coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits AT lisaetopolnik coordinationofdendriticinhibitionthroughlocaldisinhibitorycircuits |
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1725635923322863616 |