Toll-like Interleukin 1 Receptor Regulator Is an Important Modulator of Inflammation Responsive Genes

Toll-like Interleukin 1 Receptor Regulator Is an Important Modulator of Inflammation Responsive Genes

TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR express...

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Bibliographic Details
Main Authors: Mohammad Abul Kashem, Hongzhao Li, Nikki Pauline Toledo, Robert Were Omange, Binhua Liang, Lewis Ruxi Liu, Lin Li, Xuefen Yang, Xin-Yong Yuan, Jason Kindrachuk, Francis A. Plummer, Ma Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
TILRR
NFκB pathway
pro-inflammatory cytokine/chemokine(s)
innate immune response
inflammation
microbial infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00272/full

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