Hydrogels in the clinic
Abstract Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering,...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-05-01
|
Series: | Bioengineering & Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1002/btm2.10158 |
id |
doaj-8207337544974cfdaf6ff19566e400ee |
---|---|
record_format |
Article |
spelling |
doaj-8207337544974cfdaf6ff19566e400ee2020-11-25T03:17:15ZengWileyBioengineering & Translational Medicine2380-67612020-05-0152n/an/a10.1002/btm2.10158Hydrogels in the clinicAbhirup Mandal0John R. Clegg1Aaron C. Anselmo2Samir Mitragotri3John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USAJohn A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USADivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USAJohn A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USAAbstract Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, and chemistry. Advances in these fields continue to lead to invention of new polymers, new approaches to crosslink polymers, new strategies to fabricate hydrogels, and new applications arising from hydrogels for improving healthcare. Various hydrogel technologies have received regulatory approval for healthcare applications ranging from cancer treatment to aesthetic corrections to spinal fusion. Beyond these applications, hydrogels are being studied in clinical settings for tissue regeneration, incontinence, and other applications. Here, we analyze the current clinical landscape of injectable hydrogel technologies, including hydrogels that have been clinically approved or are currently being investigated in clinical settings. We summarize our analysis to highlight key clinical areas that hydrogels have found sustained success in and further discuss challenges that may limit their future clinical translation.https://doi.org/10.1002/btm2.10158clinicsdrug deliveryFDAinjectable materialsmarketed productsregenerative |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abhirup Mandal John R. Clegg Aaron C. Anselmo Samir Mitragotri |
spellingShingle |
Abhirup Mandal John R. Clegg Aaron C. Anselmo Samir Mitragotri Hydrogels in the clinic Bioengineering & Translational Medicine clinics drug delivery FDA injectable materials marketed products regenerative |
author_facet |
Abhirup Mandal John R. Clegg Aaron C. Anselmo Samir Mitragotri |
author_sort |
Abhirup Mandal |
title |
Hydrogels in the clinic |
title_short |
Hydrogels in the clinic |
title_full |
Hydrogels in the clinic |
title_fullStr |
Hydrogels in the clinic |
title_full_unstemmed |
Hydrogels in the clinic |
title_sort |
hydrogels in the clinic |
publisher |
Wiley |
series |
Bioengineering & Translational Medicine |
issn |
2380-6761 |
publishDate |
2020-05-01 |
description |
Abstract Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, and chemistry. Advances in these fields continue to lead to invention of new polymers, new approaches to crosslink polymers, new strategies to fabricate hydrogels, and new applications arising from hydrogels for improving healthcare. Various hydrogel technologies have received regulatory approval for healthcare applications ranging from cancer treatment to aesthetic corrections to spinal fusion. Beyond these applications, hydrogels are being studied in clinical settings for tissue regeneration, incontinence, and other applications. Here, we analyze the current clinical landscape of injectable hydrogel technologies, including hydrogels that have been clinically approved or are currently being investigated in clinical settings. We summarize our analysis to highlight key clinical areas that hydrogels have found sustained success in and further discuss challenges that may limit their future clinical translation. |
topic |
clinics drug delivery FDA injectable materials marketed products regenerative |
url |
https://doi.org/10.1002/btm2.10158 |
work_keys_str_mv |
AT abhirupmandal hydrogelsintheclinic AT johnrclegg hydrogelsintheclinic AT aaroncanselmo hydrogelsintheclinic AT samirmitragotri hydrogelsintheclinic |
_version_ |
1724632410895679488 |