Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral glucose-lowering agents. Apart from their glucose-lowering effects, large clinical trials assessing certain SGLT2 inhibitors have revealed cardiac and renal protective effects in non-diabetic patients. These excellent outcomes...
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doaj-820a26defa1d4fb4af00fa3b0d9309df2021-08-26T13:28:25ZengMDPI AGAntioxidants2076-39212021-07-01101166116610.3390/antiox10081166Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human DiseasesKai-Fan Tsai0Yung-Lung Chen1Terry Ting-Yu Chiou2Tian-Huei Chu3Lung-Chih Li4Hwee-Yeong Ng5Wen-Chin Lee6Chien-Te Lee7Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanSection of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral glucose-lowering agents. Apart from their glucose-lowering effects, large clinical trials assessing certain SGLT2 inhibitors have revealed cardiac and renal protective effects in non-diabetic patients. These excellent outcomes motivated scientists and clinical professionals to revisit their underlying mechanisms. In addition to the heart and kidney, redox homeostasis is crucial in several human diseases, including liver diseases, neural disorders, and cancers, with accumulating preclinical studies demonstrating the therapeutic benefits of SGLT2 inhibitors. In the present review, we aimed to update recent advances in the antioxidant roles of SGLT2 inhibitors in common but debilitating human diseases. We anticipate that this review will guide new research directions and novel therapeutic strategies for diabetes, cardiovascular diseases, nephropathies, liver diseases, neural disorders, and cancers in the era of SGLT2 inhibitors.https://www.mdpi.com/2076-3921/10/8/1166SGLT2 inhibitorsantioxidantsdiabetescardiovascular diseasesnephropathyliver diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kai-Fan Tsai Yung-Lung Chen Terry Ting-Yu Chiou Tian-Huei Chu Lung-Chih Li Hwee-Yeong Ng Wen-Chin Lee Chien-Te Lee |
spellingShingle |
Kai-Fan Tsai Yung-Lung Chen Terry Ting-Yu Chiou Tian-Huei Chu Lung-Chih Li Hwee-Yeong Ng Wen-Chin Lee Chien-Te Lee Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases Antioxidants SGLT2 inhibitors antioxidants diabetes cardiovascular diseases nephropathy liver diseases |
author_facet |
Kai-Fan Tsai Yung-Lung Chen Terry Ting-Yu Chiou Tian-Huei Chu Lung-Chih Li Hwee-Yeong Ng Wen-Chin Lee Chien-Te Lee |
author_sort |
Kai-Fan Tsai |
title |
Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases |
title_short |
Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases |
title_full |
Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases |
title_fullStr |
Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases |
title_full_unstemmed |
Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases |
title_sort |
emergence of sglt2 inhibitors as powerful antioxidants in human diseases |
publisher |
MDPI AG |
series |
Antioxidants |
issn |
2076-3921 |
publishDate |
2021-07-01 |
description |
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral glucose-lowering agents. Apart from their glucose-lowering effects, large clinical trials assessing certain SGLT2 inhibitors have revealed cardiac and renal protective effects in non-diabetic patients. These excellent outcomes motivated scientists and clinical professionals to revisit their underlying mechanisms. In addition to the heart and kidney, redox homeostasis is crucial in several human diseases, including liver diseases, neural disorders, and cancers, with accumulating preclinical studies demonstrating the therapeutic benefits of SGLT2 inhibitors. In the present review, we aimed to update recent advances in the antioxidant roles of SGLT2 inhibitors in common but debilitating human diseases. We anticipate that this review will guide new research directions and novel therapeutic strategies for diabetes, cardiovascular diseases, nephropathies, liver diseases, neural disorders, and cancers in the era of SGLT2 inhibitors. |
topic |
SGLT2 inhibitors antioxidants diabetes cardiovascular diseases nephropathy liver diseases |
url |
https://www.mdpi.com/2076-3921/10/8/1166 |
work_keys_str_mv |
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