Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study
Abstract Aim The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients. Materials and methods This cross-section...
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doaj-820fdb2a5aaa42148aab5390d7c6f7d52021-02-14T12:49:30ZengBMCArthritis Research & Therapy1478-63622020-02-0122111110.1186/s13075-020-2121-6Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional studyJerián González-Febles0Beatriz Rodríguez-Lozano1Carlos Sánchez-Piedra2Jorge Garnier-Rodríguez3Sagrario Bustabad4Martina Hernández-González5Enrique González-Dávila6Mariano Sanz7Federico Díaz-González8Departamento de Especialidades Odontológicas, Facultad de Odontología, Universidad ComplutenseServicio de Reumatología, Hospital Universitario de CanariasUnidad de Investigación de la Sociedad Española de ReumatologíaClínica Dental Dr. GarnierServicio de Reumatología, Hospital Universitario de CanariasClínica Dental Dr. GarnierDepartamento de Matemáticas, Estadística e Investigación Operativa, Universidad de La LagunaGrupo de Investigación de Etiología y Tratamiento de las Enfermedades Periodontales (ETEP), Facultad de Odontología, Universidad ComplutenseGrupo de Investigación de Etiología y Tratamiento de las Enfermedades Periodontales (ETEP), Facultad de Odontología, Universidad ComplutenseAbstract Aim The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients. Materials and methods This cross-sectional study included 164 RA patients. Socio-demographics and RA disease characteristics, including ELISA-detected ACPA (anti-CCP-2), were recorded. Exposure was assessed by periodontal parameters: plaque index (PI), bleeding on probing (BoP), probing pocket depth, and clinical attachment levels (CAL). Presence and levels of ACPAs (outcome) and exposure variables were compared by both parametric and non-parametric tests and associations were evaluated by adjusted odds ratio (OR). Results A significant association was observed between the presence of anti-CCP antibodies and severity of periodontal outcomes such as the mean CAL (OR 1.483, p = 0.036), mean PI (OR 1.029, p = 0.012), and the number of pockets ≥ 5 mm (OR 1.021, p = 0.08). High anti-CCP antibodies levels were associated with mean CAL, mean PI, and number of pockets ≥ 5 mm with an OR of 1.593 (p = 0.043), 1.060 (p < 0.001), and 1.031 (p = 0.031), respectively. Furthermore, a significant increase of 4.45 U/mL in anti-CCP antibodies levels (p = 0.002) in RA patients was found for each pocket ≥ 5 mm after adjusting for age, gender, smoking, time of disease evolution, and RA activity. Conclusions In RA patients, the severity of periodontal conditions such as mean CAL, mean PI, and the number of pockets ≥ 5 mm were linearly associated with both the presence and levels of anti-CCP antibodies.https://doi.org/10.1186/s13075-020-2121-6ACPARheumatoid factorSevere periodontitisRheumatoid arthritis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jerián González-Febles Beatriz Rodríguez-Lozano Carlos Sánchez-Piedra Jorge Garnier-Rodríguez Sagrario Bustabad Martina Hernández-González Enrique González-Dávila Mariano Sanz Federico Díaz-González |
spellingShingle |
Jerián González-Febles Beatriz Rodríguez-Lozano Carlos Sánchez-Piedra Jorge Garnier-Rodríguez Sagrario Bustabad Martina Hernández-González Enrique González-Dávila Mariano Sanz Federico Díaz-González Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study Arthritis Research & Therapy ACPA Rheumatoid factor Severe periodontitis Rheumatoid arthritis |
author_facet |
Jerián González-Febles Beatriz Rodríguez-Lozano Carlos Sánchez-Piedra Jorge Garnier-Rodríguez Sagrario Bustabad Martina Hernández-González Enrique González-Dávila Mariano Sanz Federico Díaz-González |
author_sort |
Jerián González-Febles |
title |
Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study |
title_short |
Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study |
title_full |
Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study |
title_fullStr |
Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study |
title_full_unstemmed |
Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study |
title_sort |
association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2020-02-01 |
description |
Abstract Aim The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients. Materials and methods This cross-sectional study included 164 RA patients. Socio-demographics and RA disease characteristics, including ELISA-detected ACPA (anti-CCP-2), were recorded. Exposure was assessed by periodontal parameters: plaque index (PI), bleeding on probing (BoP), probing pocket depth, and clinical attachment levels (CAL). Presence and levels of ACPAs (outcome) and exposure variables were compared by both parametric and non-parametric tests and associations were evaluated by adjusted odds ratio (OR). Results A significant association was observed between the presence of anti-CCP antibodies and severity of periodontal outcomes such as the mean CAL (OR 1.483, p = 0.036), mean PI (OR 1.029, p = 0.012), and the number of pockets ≥ 5 mm (OR 1.021, p = 0.08). High anti-CCP antibodies levels were associated with mean CAL, mean PI, and number of pockets ≥ 5 mm with an OR of 1.593 (p = 0.043), 1.060 (p < 0.001), and 1.031 (p = 0.031), respectively. Furthermore, a significant increase of 4.45 U/mL in anti-CCP antibodies levels (p = 0.002) in RA patients was found for each pocket ≥ 5 mm after adjusting for age, gender, smoking, time of disease evolution, and RA activity. Conclusions In RA patients, the severity of periodontal conditions such as mean CAL, mean PI, and the number of pockets ≥ 5 mm were linearly associated with both the presence and levels of anti-CCP antibodies. |
topic |
ACPA Rheumatoid factor Severe periodontitis Rheumatoid arthritis |
url |
https://doi.org/10.1186/s13075-020-2121-6 |
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