Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China
Abstract Background Chlamydia trachomatis (CT) infection is one of the most pervasive sexually transmitted infections and has high prevalence in urogenital and extra-urogenital sites among men who have sex with men (MSM). This study investigated anatomical site-specific prevalence and genotypes of C...
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doaj-82279e1096e54ceab5ca74467f0183a52020-12-13T12:07:10ZengBMCBMC Infectious Diseases1471-23342019-12-011911910.1186/s12879-019-4664-1Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in ChinaYing Zhou0Yu-Mao Cai1Shi-Liang Li2Ning-Xiao Cao3Xiao-Feng Zhu4Feng Wang5Yan Han6Yue-Ping Yin7Xiang-Sheng Chen8Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical CollegeShenzhen Center for Chronic Disease ControlWuhan Institute of DermatologyInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical CollegeShenzhen Center for Chronic Disease ControlInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical CollegeInstitute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical CollegeAbstract Background Chlamydia trachomatis (CT) infection is one of the most pervasive sexually transmitted infections and has high prevalence in urogenital and extra-urogenital sites among men who have sex with men (MSM). This study investigated anatomical site-specific prevalence and genotypes of CT among MSM recruited from three geographic areas in China. Methods We collected urine specimens and anorectal, pharyngeal swab specimens from 379 MSM. CT infection was identified using polymerase chain reaction and CT genotyping was determined by sequences of the ompA gene. Results The results indicated that the overall prevalence of CT infection was 18.2% (95% confidence intervals [CIs], 13.9–22.5%) and significantly different between the cities (p = 0.048). The infection was most common at the anorectal site (15.6, 95%CIs 11.6–19.5%) followed by urethral (3.2, 95%CIs 1.4–5.0%) and oropharyngeal sites (1.6, 95%CIs 0.3–2.9%). Genotypes D and G were the most common CT strains in this population but genotype D was significantly predominated in Nanjing while genotype G was in Wuhan. No genotype related to lymphogranuloma venereum was found. CT infection was significantly related to the infection of Neisseria gonorrhoeae (adjusted odds ratio [aOR] 14.27, 95%CIs 6.02–33.83, p < 0.001) and age. Men older than 40 years old were less likely to have a CT infection as compared to men under 30 years old (aOR 0.37, 95% CIs 0.15–0.93, p = 0.03). Conclusion The high CT infection prevalence, particularly in the anorectal site, among MSM suggests the necessity to development an integrated CT screening and treatment program specifically focusing on this high-risk population. Surveillance of CT infections should be improved by including both infection and genotype based surveys into the current surveillance programs in China.https://doi.org/10.1186/s12879-019-4664-1Chlamydia trachomatisPrevalenceGenotypeMSMChina |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Zhou Yu-Mao Cai Shi-Liang Li Ning-Xiao Cao Xiao-Feng Zhu Feng Wang Yan Han Yue-Ping Yin Xiang-Sheng Chen |
spellingShingle |
Ying Zhou Yu-Mao Cai Shi-Liang Li Ning-Xiao Cao Xiao-Feng Zhu Feng Wang Yan Han Yue-Ping Yin Xiang-Sheng Chen Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China BMC Infectious Diseases Chlamydia trachomatis Prevalence Genotype MSM China |
author_facet |
Ying Zhou Yu-Mao Cai Shi-Liang Li Ning-Xiao Cao Xiao-Feng Zhu Feng Wang Yan Han Yue-Ping Yin Xiang-Sheng Chen |
author_sort |
Ying Zhou |
title |
Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China |
title_short |
Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China |
title_full |
Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China |
title_fullStr |
Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China |
title_full_unstemmed |
Anatomical site prevalence and genotypes of Chlamydia trachomatis infections among men who have sex with men: a multi-site study in China |
title_sort |
anatomical site prevalence and genotypes of chlamydia trachomatis infections among men who have sex with men: a multi-site study in china |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2019-12-01 |
description |
Abstract Background Chlamydia trachomatis (CT) infection is one of the most pervasive sexually transmitted infections and has high prevalence in urogenital and extra-urogenital sites among men who have sex with men (MSM). This study investigated anatomical site-specific prevalence and genotypes of CT among MSM recruited from three geographic areas in China. Methods We collected urine specimens and anorectal, pharyngeal swab specimens from 379 MSM. CT infection was identified using polymerase chain reaction and CT genotyping was determined by sequences of the ompA gene. Results The results indicated that the overall prevalence of CT infection was 18.2% (95% confidence intervals [CIs], 13.9–22.5%) and significantly different between the cities (p = 0.048). The infection was most common at the anorectal site (15.6, 95%CIs 11.6–19.5%) followed by urethral (3.2, 95%CIs 1.4–5.0%) and oropharyngeal sites (1.6, 95%CIs 0.3–2.9%). Genotypes D and G were the most common CT strains in this population but genotype D was significantly predominated in Nanjing while genotype G was in Wuhan. No genotype related to lymphogranuloma venereum was found. CT infection was significantly related to the infection of Neisseria gonorrhoeae (adjusted odds ratio [aOR] 14.27, 95%CIs 6.02–33.83, p < 0.001) and age. Men older than 40 years old were less likely to have a CT infection as compared to men under 30 years old (aOR 0.37, 95% CIs 0.15–0.93, p = 0.03). Conclusion The high CT infection prevalence, particularly in the anorectal site, among MSM suggests the necessity to development an integrated CT screening and treatment program specifically focusing on this high-risk population. Surveillance of CT infections should be improved by including both infection and genotype based surveys into the current surveillance programs in China. |
topic |
Chlamydia trachomatis Prevalence Genotype MSM China |
url |
https://doi.org/10.1186/s12879-019-4664-1 |
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