The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold
The living environment of bone cells is a complex curved one. And based on the modeling method of triply periodic minimal surfaces (TPMS) can be used to design a variety of complex surface structures, so it has been more and more widely studied and applied. In this paper, the main research object is...
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doaj-822a8ff6db1c4cf890b609274c6d4be42020-11-25T03:41:17ZengElsevierMaterials & Design0264-12752020-08-01193108830The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffoldSu Wang0Zhang'ao Shi1Linlin Liu2Xin Zhou3Luchuang Zhu4Yongqiang Hao5School of Mechanical Engineering, Sichuan University, Chengdu 610065, ChinaSchool of Mechanical Engineering, Sichuan University, Chengdu 610065, China; Corresponding author.School of Mechanical Engineering, Sichuan University, Chengdu 610065, ChinaSchool of Mechanical Engineering, Sichuan University, Chengdu 610065, ChinaSchool of Mechanical Engineering, Sichuan University, Chengdu 610065, ChinaDepartment of Orthopaedic Surgery, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, ChinaThe living environment of bone cells is a complex curved one. And based on the modeling method of triply periodic minimal surfaces (TPMS) can be used to design a variety of complex surface structures, so it has been more and more widely studied and applied. In this paper, the main research object is the Primitive structure of TPMS. As an artificial bone scaffold structure, it must possess good mechanical properties, permeability, and is conducive to cell adhesion and proliferation. In this study, several groups of Ti6Al4V Primitive models are designed and fabricated by selective laser melting (SLM). The mechanical properties of scaffold are evaluated by mechanical compression test. The morphology of the scaffold model is characterized. The permeability of the scaffold was predicted and evaluated by computational fluid dynamics (CFD) analyses. Finally, the evaluation of the effects of Ti6A14V scaffold on cell growth is conducted by cytotoxicity test. The results show that the mechanical properties and permeability of the designed Primitive surface scaffold are pretty good as bone tissue replacement. Among them, the Psy scaffold with pore size and porosity varying along the axisymmetric gradient has significant research and application potential in the field of artificial bone scaffold.http://www.sciencedirect.com/science/article/pii/S0264127520303646Selective laser meltingTPMSBiomimetic bone scaffoldMechanical propertyPermeabilityTi6Al4V |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Su Wang Zhang'ao Shi Linlin Liu Xin Zhou Luchuang Zhu Yongqiang Hao |
spellingShingle |
Su Wang Zhang'ao Shi Linlin Liu Xin Zhou Luchuang Zhu Yongqiang Hao The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold Materials & Design Selective laser melting TPMS Biomimetic bone scaffold Mechanical property Permeability Ti6Al4V |
author_facet |
Su Wang Zhang'ao Shi Linlin Liu Xin Zhou Luchuang Zhu Yongqiang Hao |
author_sort |
Su Wang |
title |
The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold |
title_short |
The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold |
title_full |
The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold |
title_fullStr |
The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold |
title_full_unstemmed |
The design of Ti6Al4V Primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold |
title_sort |
design of ti6al4v primitive surface structure with symmetrical gradient of pore size in biomimetic bone scaffold |
publisher |
Elsevier |
series |
Materials & Design |
issn |
0264-1275 |
publishDate |
2020-08-01 |
description |
The living environment of bone cells is a complex curved one. And based on the modeling method of triply periodic minimal surfaces (TPMS) can be used to design a variety of complex surface structures, so it has been more and more widely studied and applied. In this paper, the main research object is the Primitive structure of TPMS. As an artificial bone scaffold structure, it must possess good mechanical properties, permeability, and is conducive to cell adhesion and proliferation. In this study, several groups of Ti6Al4V Primitive models are designed and fabricated by selective laser melting (SLM). The mechanical properties of scaffold are evaluated by mechanical compression test. The morphology of the scaffold model is characterized. The permeability of the scaffold was predicted and evaluated by computational fluid dynamics (CFD) analyses. Finally, the evaluation of the effects of Ti6A14V scaffold on cell growth is conducted by cytotoxicity test. The results show that the mechanical properties and permeability of the designed Primitive surface scaffold are pretty good as bone tissue replacement. Among them, the Psy scaffold with pore size and porosity varying along the axisymmetric gradient has significant research and application potential in the field of artificial bone scaffold. |
topic |
Selective laser melting TPMS Biomimetic bone scaffold Mechanical property Permeability Ti6Al4V |
url |
http://www.sciencedirect.com/science/article/pii/S0264127520303646 |
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