Establishment and evaluation of a novel mouse model of peri/postmenopausal depression

Women are believed to be more vulnerable to develop depressive symptoms during the perimenopause compared to postmenopause. The traditional bilateral ovariectomy and chronic mild stress (CMS) stimulation animal model produces a postmenopausal depressive-like state but the transition from perimenopau...

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Bibliographic Details
Main Authors: Ling Zhang, Lu-Lu Cao, Dan-Dan Yang, Jian-Hua Ding, Xu-Dong Guo, Teng-Fei Xue, Xiao-Jie Zhao, Xiu-Lan Sun
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018339343