Molecular mechanisms of Treg-mediated T cell suppression

Molecular mechanisms of Treg-mediated T cell suppression

CD4+CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs prevent autoimmune disease and allergies. On the other hand, Tregs can avert immune reactions against tumors and pathogens. Despite the...

Full description

Bibliographic Details
Main Authors: Angelika eSchmidt, Nina eOberle, Peter H. Krammer
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-03-01
Series:Frontiers in Immunology
Subjects:
Treg
suppression mechanisms
TCR signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00051/full

Similar Items