Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy
We aimed to evaluate muscle mass changes after injection of botulinum toxin (BoNT) in children with spastic hemiplegic cerebral palsy (CP). Children aged between 2 and 12 years who were diagnosed with hemiplegic CP with spastic equinus foot were prospectively recruited and administered BoNT in the a...
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doaj-826224603bdf4c56b30bf492f3c083c12021-04-14T23:01:12ZengMDPI AGToxins2072-66512021-04-011327827810.3390/toxins13040278Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral PalsyDongwoo Lee0Jaewon Kim1Ja-Young Oh2Mi-Hyang Han3Da-Ye Kim4Ji-Hye Kang5Dae-Hyun Jang6Department of Rehabilitation Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaWe aimed to evaluate muscle mass changes after injection of botulinum toxin (BoNT) in children with spastic hemiplegic cerebral palsy (CP). Children aged between 2 and 12 years who were diagnosed with hemiplegic CP with spastic equinus foot were prospectively recruited and administered BoNT in the affected leg. Lean body mass (LBM) of both legs and total limbs was measured by dual-energy X-ray absorptiometry (DXA) preinjection and 4 and 12 weeks after injection. A total of 15 children were enrolled into the study. LBM of both legs and total limbs increased significantly over 12 weeks of growth. The ratio of LBM of the affected leg to total limbs and to the unaffected leg significantly reduced at 4 weeks after injection compared with preinjection but significantly increased at 12 weeks after injection compared with 4 weeks after injection. In conclusion, the muscle mass of the affected leg after BoNT injection in children with hemiplegic spastic CP decreased at 4 weeks after BoNT injection but significantly recovered after 12 weeks after injection.https://www.mdpi.com/2072-6651/13/4/278cerebral palsybotulinum toxinsmuscular atrophyspasticitymuscle mass |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dongwoo Lee Jaewon Kim Ja-Young Oh Mi-Hyang Han Da-Ye Kim Ji-Hye Kang Dae-Hyun Jang |
spellingShingle |
Dongwoo Lee Jaewon Kim Ja-Young Oh Mi-Hyang Han Da-Ye Kim Ji-Hye Kang Dae-Hyun Jang Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy Toxins cerebral palsy botulinum toxins muscular atrophy spasticity muscle mass |
author_facet |
Dongwoo Lee Jaewon Kim Ja-Young Oh Mi-Hyang Han Da-Ye Kim Ji-Hye Kang Dae-Hyun Jang |
author_sort |
Dongwoo Lee |
title |
Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy |
title_short |
Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy |
title_full |
Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy |
title_fullStr |
Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy |
title_full_unstemmed |
Changes in Muscle Mass after Botulinum Toxin Injection in Children with Spastic Hemiplegic Cerebral Palsy |
title_sort |
changes in muscle mass after botulinum toxin injection in children with spastic hemiplegic cerebral palsy |
publisher |
MDPI AG |
series |
Toxins |
issn |
2072-6651 |
publishDate |
2021-04-01 |
description |
We aimed to evaluate muscle mass changes after injection of botulinum toxin (BoNT) in children with spastic hemiplegic cerebral palsy (CP). Children aged between 2 and 12 years who were diagnosed with hemiplegic CP with spastic equinus foot were prospectively recruited and administered BoNT in the affected leg. Lean body mass (LBM) of both legs and total limbs was measured by dual-energy X-ray absorptiometry (DXA) preinjection and 4 and 12 weeks after injection. A total of 15 children were enrolled into the study. LBM of both legs and total limbs increased significantly over 12 weeks of growth. The ratio of LBM of the affected leg to total limbs and to the unaffected leg significantly reduced at 4 weeks after injection compared with preinjection but significantly increased at 12 weeks after injection compared with 4 weeks after injection. In conclusion, the muscle mass of the affected leg after BoNT injection in children with hemiplegic spastic CP decreased at 4 weeks after BoNT injection but significantly recovered after 12 weeks after injection. |
topic |
cerebral palsy botulinum toxins muscular atrophy spasticity muscle mass |
url |
https://www.mdpi.com/2072-6651/13/4/278 |
work_keys_str_mv |
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