Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer
Aims: Recent studies have demonstrated that microRNAs (miRNAs) can serve as useful biomarkers for human cancers. The aim of this study was to evaluate the expression level of serum miRNA-206 in patients with gastric cancer (GC) and investigate its diagnostic and prognostic value. Methods: Quantitati...
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Cell Physiol Biochem Press GmbH & Co KG
2016-09-01
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doaj-826708f5fa4240cdbe1240f42391c0b92020-11-25T02:40:28ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782016-09-013941512152010.1159/000447854447854Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric CancerCheng-Gong HouXiang-Yu LuoGang LiAims: Recent studies have demonstrated that microRNAs (miRNAs) can serve as useful biomarkers for human cancers. The aim of this study was to evaluate the expression level of serum miRNA-206 in patients with gastric cancer (GC) and investigate its diagnostic and prognostic value. Methods: Quantitative real-time PCR was performed to evaluate serum miRNA-206 levels in 150 GC patients and 150 healthy volunteers. The association between miRNA-206 expression and clinicopathological factors as well as patient's survival was analyzed. Receiver operator curve (ROC) analysis was carried out to assess the potential value of serum miRNA-206 for GC diagnosis. Results: Serum miRNA-206 was down-regulated in GC patients compared with healthy controls (P Conclusions: These results suggest that serum miRNA-206 might not only serve as a novel diagnostic biomarker for GC, but also predict cancer recurrence and patient's prognosis.http://www.karger.com/Article/FullText/447854PrognosisMiRNA-206BiomarkerGastric cancerDiagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng-Gong Hou Xiang-Yu Luo Gang Li |
spellingShingle |
Cheng-Gong Hou Xiang-Yu Luo Gang Li Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer Cellular Physiology and Biochemistry Prognosis MiRNA-206 Biomarker Gastric cancer Diagnosis |
author_facet |
Cheng-Gong Hou Xiang-Yu Luo Gang Li |
author_sort |
Cheng-Gong Hou |
title |
Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer |
title_short |
Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer |
title_full |
Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer |
title_fullStr |
Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer |
title_full_unstemmed |
Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer |
title_sort |
diagnostic and prognostic value of serum microrna-206 in patients with gastric cancer |
publisher |
Cell Physiol Biochem Press GmbH & Co KG |
series |
Cellular Physiology and Biochemistry |
issn |
1015-8987 1421-9778 |
publishDate |
2016-09-01 |
description |
Aims: Recent studies have demonstrated that microRNAs (miRNAs) can serve as useful biomarkers for human cancers. The aim of this study was to evaluate the expression level of serum miRNA-206 in patients with gastric cancer (GC) and investigate its diagnostic and prognostic value. Methods: Quantitative real-time PCR was performed to evaluate serum miRNA-206 levels in 150 GC patients and 150 healthy volunteers. The association between miRNA-206 expression and clinicopathological factors as well as patient's survival was analyzed. Receiver operator curve (ROC) analysis was carried out to assess the potential value of serum miRNA-206 for GC diagnosis. Results: Serum miRNA-206 was down-regulated in GC patients compared with healthy controls (P Conclusions: These results suggest that serum miRNA-206 might not only serve as a novel diagnostic biomarker for GC, but also predict cancer recurrence and patient's prognosis. |
topic |
Prognosis MiRNA-206 Biomarker Gastric cancer Diagnosis |
url |
http://www.karger.com/Article/FullText/447854 |
work_keys_str_mv |
AT chenggonghou diagnosticandprognosticvalueofserummicrorna206inpatientswithgastriccancer AT xiangyuluo diagnosticandprognosticvalueofserummicrorna206inpatientswithgastriccancer AT gangli diagnosticandprognosticvalueofserummicrorna206inpatientswithgastriccancer |
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