Effect of dexmedetomidine combined with propofol on stress response and early cognitive function in hypertensive patients undergoing painless gastroscopy
Objective: To investigate the effect of dexmedetomidine combined with propofol on stress response and early cognitive function in hypertensive patients undergoing painless gastroscopy. Methods: A total of 70 cases of hypertensive patients undergoing painless gastroscopy from March 2016 to March 2...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-09-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201717/36.pdf |
Summary: | Objective: To investigate the effect of dexmedetomidine combined with propofol on stress
response and early cognitive function in hypertensive patients undergoing painless gastroscopy.
Methods: A total of 70 cases of hypertensive patients undergoing painless gastroscopy from
March 2016 to March 2017 were selected as the subjects. They were randomly divided into the
observation group and the control group. The control group was injected with physiological
saline before injection and injected with propofol 2 mg/kg. The observation group was
injected with propofol 0.4 g/kg before injection, and 1 mg/kg by intravenous injection of
propofol. 2 groups of patients before administration (T0), after administration (T1), gastroscopy
(T2), gastroscope examination at the end of the 10 min (T3) collected venous blood, plasma
epinephrine by radioimmunoassay (E), norepinephrine (NE), cortisol (COR) levels of T0
records; T1, T2, T3 at the time of breathing (HR), mean arterial pressure (MAP); after 5 min,
30 min, 3 h, 6 h was evaluated with mini mental state examination (MMSE) to evaluate the
cognitive function in early stage. Results: 2 groups of patients with T1, NE, COR levels of
plasma E and T0 no significant difference, T2, T3, NE, COR and plasma E levels higher than the
T0 level, the observation group T2, T3, NE, plasma E COR levels lower than the control group,
there was statistical significance the difference between the 2 groups; the control group T1 HR
is slower than T0, MAP less than T0, T2, T3 HR faster than T0, MAP is higher than T0, and the
observation group HR and MAP each time point did not change significantly between the 2
groups was statistically significant the difference; after 5 min and 30 min compared with the
preoperative MMSE score decreased 1 D, 3 h after operation, the 6 h gradually increased, but
the observation group after 3 h MMSE score higher than the control group, the difference was
statistically significant. Conclusion: Dexmedetomidine combined with propofol can reduce
the stress reaction of patients with hypertension during painless gastroscopy, and reduce the
early understanding of the occurrence of dysfunction, which is worthy of clinical promotion. |
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ISSN: | 1007-1237 1007-1237 |