Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis
Introduction: Recurrent aphthous stomatitis (RAS) is defined by recurring ulcers restricted to oral mucosa in the patients with no other signs of systemic disease. The purpose of this study was to evaluate the salivary level of interferon gamma in patients with RAS. Methods: In this case-control stu...
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Shahid Sadoughi University of Medical Sciences
2020-11-01
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doaj-8275ba21bd814ec0ac02f534fd358e822020-12-15T05:43:10ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332020-11-0128930093016Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous StomatitisMarieh Honarmand0Ramin Saravani1Hossein Ansari2Iman Teimoori3 Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Health Promotion Research Center, Department of Biostatistics and Epidemiology, School of Health, Zahedan University of Medical Sciences, Zahedan, Iran. Dental School, Zahedan University of Medical Sciences, Zahedan, Iran. Introduction: Recurrent aphthous stomatitis (RAS) is defined by recurring ulcers restricted to oral mucosa in the patients with no other signs of systemic disease. The purpose of this study was to evaluate the salivary level of interferon gamma in patients with RAS. Methods: In this case-control study, 30 patients with RAS (in Recurrence and recovery period) in the experimental and 25 healthy people as the control group were compared. Salivary interferon gamma level was evaluated by the use of ELISA method. Data were analyzed via SPSS version 16 software with Mann-U-Whitney test and Wilcoxon. P <0.05 was considered significant. Results: The mean salivary interferon gamma levels were 45.01±31.02 pg/ml and 32.04±19.02 pg/ml in the patients with RAS and healthy individuals, respectively. (P>0.001). In addition, interferon gamma level was 45.01± 31.02 pg/ml and 58.03± 52.04 pg/ml in the recurrence and recovery periods, respectively. (P=0.67). Conclusion: Salivary interferon gamma levels were higher in the patients with RAS than healthy individuals.http://jssu.ssu.ac.ir/article-1-4955-en.htmlrecurrent aphthous stomatitisinterferon gammasaliva. |
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DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Marieh Honarmand Ramin Saravani Hossein Ansari Iman Teimoori |
spellingShingle |
Marieh Honarmand Ramin Saravani Hossein Ansari Iman Teimoori Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd recurrent aphthous stomatitis interferon gamma saliva. |
author_facet |
Marieh Honarmand Ramin Saravani Hossein Ansari Iman Teimoori |
author_sort |
Marieh Honarmand |
title |
Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis |
title_short |
Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis |
title_full |
Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis |
title_fullStr |
Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis |
title_full_unstemmed |
Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis |
title_sort |
evaluation of salivary interferon-gamma level in patients with recurrent aphthous stomatitis |
publisher |
Shahid Sadoughi University of Medical Sciences |
series |
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
issn |
2228-5741 2228-5733 |
publishDate |
2020-11-01 |
description |
Introduction: Recurrent aphthous stomatitis (RAS) is defined by recurring ulcers restricted to oral mucosa in the patients with no other signs of systemic disease. The purpose of this study was to evaluate the salivary level of interferon gamma in patients with RAS.
Methods: In this case-control study, 30 patients with RAS (in Recurrence and recovery period) in the experimental and 25 healthy people as the control group were compared. Salivary interferon gamma level was evaluated by the use of ELISA method. Data were analyzed via SPSS version 16 software with Mann-U-Whitney test and Wilcoxon. P <0.05 was considered significant.
Results: The mean salivary interferon gamma levels were 45.01±31.02 pg/ml and 32.04±19.02 pg/ml in the patients with RAS and healthy individuals, respectively. (P>0.001). In addition, interferon gamma level was 45.01± 31.02 pg/ml and 58.03± 52.04 pg/ml in the recurrence and recovery periods, respectively. (P=0.67).
Conclusion: Salivary interferon gamma levels were higher in the patients with RAS than healthy individuals. |
topic |
recurrent aphthous stomatitis interferon gamma saliva. |
url |
http://jssu.ssu.ac.ir/article-1-4955-en.html |
work_keys_str_mv |
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