Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Abstract Many compounds that appear promising in preclinical species, fail in human clinical trials due to safety concerns. The FDA has strongly encouraged the application of modeling in drug development to improve product safety. This study illustrates how DILIsym, a computational representation of...

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Bibliographic Details
Main Authors: Grant Generaux, Vinal V. Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Keith Riccardi, Li Di, Brett A. Howell, Scott Q. Siler, Paul B. Watkins, Hugh A. Barton, Michael D. Aleo, Lisl K. M. Shoda
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Pharmacology Research & Perspectives
Subjects:
bile acid transporters
DILIsym
drug‐induced liver injury
mechanistic
mitochondria
PBPK
Online Access:https://doi.org/10.1002/prp2.523

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