The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respira...
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doaj-828d67f4965142e48d55c8d7fef513fd2021-04-06T04:13:44ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-04-011310.3389/fnagi.2021.632673632673The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in PatientsIsabel M. Alonso-Bellido0Isabel M. Alonso-Bellido1Sara Bachiller2Sara Bachiller3Guillermo Vázquez4Guillermo Vázquez5Luis Cruz-Hernández6Luis Cruz-Hernández7Emilio Martínez8Emilio Martínez9Ezequiel Ruiz-Mateos10Tomas Deierborg11José L. Venero12José L. Venero13Luis M. Real14Luis M. Real15Rocío Ruiz16Rocío Ruiz17Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainInstituto de Biomedicina de Sevilla-Hospital, Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainExperimental Neuroinflammation Laboratory, Department of Experimental Medical Science, Biomedical Center, Lund University, Lund, SwedenUnidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainDepartamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainInstituto de Biomedicina de Sevilla-Hospital, Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainDepartamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainInstituto de Biomedicina de Sevilla-Hospital, Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainDepartamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainInstituto de Biomedicina de Sevilla-Hospital, Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainUnidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainExperimental Neuroinflammation Laboratory, Department of Experimental Medical Science, Biomedical Center, Lund University, Lund, SwedenDepartamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainInstituto de Biomedicina de Sevilla-Hospital, Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, SpainDepartamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, SpainDepartamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, SpainInstituto de Biomedicina de Sevilla-Hospital, Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, SpainThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation.https://www.frontiersin.org/articles/10.3389/fnagi.2021.632673/fullcoronavirusCOVID-19SARS-CoV-2neurologicalnervous system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isabel M. Alonso-Bellido Isabel M. Alonso-Bellido Sara Bachiller Sara Bachiller Guillermo Vázquez Guillermo Vázquez Luis Cruz-Hernández Luis Cruz-Hernández Emilio Martínez Emilio Martínez Ezequiel Ruiz-Mateos Tomas Deierborg José L. Venero José L. Venero Luis M. Real Luis M. Real Rocío Ruiz Rocío Ruiz |
spellingShingle |
Isabel M. Alonso-Bellido Isabel M. Alonso-Bellido Sara Bachiller Sara Bachiller Guillermo Vázquez Guillermo Vázquez Luis Cruz-Hernández Luis Cruz-Hernández Emilio Martínez Emilio Martínez Ezequiel Ruiz-Mateos Tomas Deierborg José L. Venero José L. Venero Luis M. Real Luis M. Real Rocío Ruiz Rocío Ruiz The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients Frontiers in Aging Neuroscience coronavirus COVID-19 SARS-CoV-2 neurological nervous system |
author_facet |
Isabel M. Alonso-Bellido Isabel M. Alonso-Bellido Sara Bachiller Sara Bachiller Guillermo Vázquez Guillermo Vázquez Luis Cruz-Hernández Luis Cruz-Hernández Emilio Martínez Emilio Martínez Ezequiel Ruiz-Mateos Tomas Deierborg José L. Venero José L. Venero Luis M. Real Luis M. Real Rocío Ruiz Rocío Ruiz |
author_sort |
Isabel M. Alonso-Bellido |
title |
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients |
title_short |
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients |
title_full |
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients |
title_fullStr |
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients |
title_full_unstemmed |
The Other Side of SARS-CoV-2 Infection: Neurological Sequelae in Patients |
title_sort |
other side of sars-cov-2 infection: neurological sequelae in patients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-04-01 |
description |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase of COVID-19 has been also related to nervous system symptoms, including loss of taste and smell as well as encephalitis and cerebrovascular disorders. However, it remains unclear if neurological complications are due to the direct viral infection of the nervous system, or they appear as a consequence of the immune reaction against the virus in patients who presented pre-existing deficits or had a certain detrimental immune response. Importantly, the medium and long-term consequences of the infection by SARS-CoV-2 in the nervous system remain at present unknown. This review article aims to give an overview of the current neurological symptoms associated with COVID-19, as well as attempting to provide an insight beyond the acute affectation. |
topic |
coronavirus COVID-19 SARS-CoV-2 neurological nervous system |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.632673/full |
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