Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium

Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium

Cholesterol-containing soft drusen and subretinal drusenoid deposits (SDDs) occur at the basolateral and apical side of the retinal pigment epithelium (RPE), respectively, in the chorioretina and are independent risk factors for late age-related macular degeneration (AMD). Cholesterol in these depos...

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Bibliographic Details
Main Authors: Nicholas N. Lyssenko, Naqi Haider, Antonino Picataggi, Eleonora Cipollari, Wanzhen Jiao, Michael C. Phillips, Daniel J. Rader, Venkata Ramana Murthy Chavali
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Journal of Lipid Research
Subjects:
adenosine triphosphate-binding cassette transporter A1
apolipoprotein B
high density lipoproteins
oxidized lipids
age-related macular degeneration
soft drusen
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520341845

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http://www.sciencedirect.com/science/article/pii/S0022227520341845

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