WASH maintains NKp46+ ILC3 cells by promoting AHR expression

WASH maintains NKp46+ ILC3 cells by promoting AHR expression

Innate lymphoid cells (ILC) are thought to direct immune responses, but little is known about the development and maintenance of ILC subsets. Here the authors show that WASH maintains the pool of NKp46+ ILC3s by recruiting Arid1a to the aryl hydrocarbon receptor promoter and inducing its expression.

Bibliographic Details
Main Authors: Pengyan Xia, Jing Liu, Shuo Wang, Buqing Ye, Ying Du, Zhen Xiong, Ze-Guang Han, Liang Tong, Zusen Fan
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15685
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spelling doaj-82ad5b38f43c48979a1f9a1fb0f01cd22021-05-11T07:18:13ZengNature Publishing GroupNature Communications2041-17232017-06-018111210.1038/ncomms15685WASH maintains NKp46+ ILC3 cells by promoting AHR expressionPengyan Xia0Jing Liu1Shuo Wang2Buqing Ye3Ying Du4Zhen Xiong5Ze-Guang Han6Liang Tong7Zusen Fan8Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesKey Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong UniversityDepartment of Biological Sciences, Columbia UniversityKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesInnate lymphoid cells (ILC) are thought to direct immune responses, but little is known about the development and maintenance of ILC subsets. Here the authors show that WASH maintains the pool of NKp46+ ILC3s by recruiting Arid1a to the aryl hydrocarbon receptor promoter and inducing its expression.https://doi.org/10.1038/ncomms15685
collection DOAJ
language English
format Article
sources DOAJ
author Pengyan Xia
Jing Liu
Shuo Wang
Buqing Ye
Ying Du
Zhen Xiong
Ze-Guang Han
Liang Tong
Zusen Fan
spellingShingle Pengyan Xia
Jing Liu
Shuo Wang
Buqing Ye
Ying Du
Zhen Xiong
Ze-Guang Han
Liang Tong
Zusen Fan
WASH maintains NKp46+ ILC3 cells by promoting AHR expression
Nature Communications
author_facet Pengyan Xia
Jing Liu
Shuo Wang
Buqing Ye
Ying Du
Zhen Xiong
Ze-Guang Han
Liang Tong
Zusen Fan
author_sort Pengyan Xia
title WASH maintains NKp46+ ILC3 cells by promoting AHR expression
title_short WASH maintains NKp46+ ILC3 cells by promoting AHR expression
title_full WASH maintains NKp46+ ILC3 cells by promoting AHR expression
title_fullStr WASH maintains NKp46+ ILC3 cells by promoting AHR expression
title_full_unstemmed WASH maintains NKp46+ ILC3 cells by promoting AHR expression
title_sort wash maintains nkp46+ ilc3 cells by promoting ahr expression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Innate lymphoid cells (ILC) are thought to direct immune responses, but little is known about the development and maintenance of ILC subsets. Here the authors show that WASH maintains the pool of NKp46+ ILC3s by recruiting Arid1a to the aryl hydrocarbon receptor promoter and inducing its expression.
url https://doi.org/10.1038/ncomms15685
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AT jingliu washmaintainsnkp46ilc3cellsbypromotingahrexpression
AT shuowang washmaintainsnkp46ilc3cellsbypromotingahrexpression
AT buqingye washmaintainsnkp46ilc3cellsbypromotingahrexpression
AT yingdu washmaintainsnkp46ilc3cellsbypromotingahrexpression
AT zhenxiong washmaintainsnkp46ilc3cellsbypromotingahrexpression
AT zeguanghan washmaintainsnkp46ilc3cellsbypromotingahrexpression
AT liangtong washmaintainsnkp46ilc3cellsbypromotingahrexpression
AT zusenfan washmaintainsnkp46ilc3cellsbypromotingahrexpression
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