Correlation of thrombotic factor with bleeding severity in patient’s with factor XI deficiency

• Main Authors: Mohammad Faranoush, Ali Jafarpoor, Raheb Ghorbani, Mahbobeh Rahmani, Mohammad Jazebi, Tahereh Shashaani, Navid Danaie, Gholamreza Mohamadi
• Format: Article
• Language: fas
• Published: Semnan Univeristy of Medical Sciences 2009-10-01
• Series: Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān
• Subjects: Factor XI; Thrombotic factor; Coagulation factor; Bleeding severity
• Online Access: http://www.koomeshjournal.ir/browse.php?a_code=A-10-4-390&slc_lang=en&sid=1&ftxt=1

Introduction: Factor XI is a glycoprotein that important role in blood coagulation. The aim of thisstudy is determine correlation of thrombotic factor and bleeding severity with factor XI deficiency.Materials and Methods: 24 patients with factor XI deficiency were included in this study. Followingphysical examination and interview, a questionnaire was filled for all the patients. A blood sample wascollected for measurement of coagulation factors (II, V, VII, and VIII, IX, X, XI, XII, and XIII),fibrinogen, protein C, protein S, antithrombin III, PG20210A, factor V Leiden, MTHFR gene andHomocystein.Results: 54.2% and 45.8% of patients were male and female, respectively. Mean (±SD) age of patientswas 27.2±13.6 (3-49) years. 45.8%, 29.2%, 25% of the patients showed mild, moderate and severebleeding, respectively. Although, a significant positive correlation was observed between factor V andbleeding severity (P=0.033, r =0.491), there was no correlation between bleeding severity and otherthrombotic factors.Conclusion: The findings showed that a positive correlation between factor XI deficiency and factorV. We need more studies as multicenter studies to detecting the relation of other thrombotic factors withbleeding severity in patients with factor XI deficiency.