Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials
Nosocomial bacterial infections are associated with high morbidity and mortality, posing a huge burden to healthcare systems worldwide. The ongoing COVID-19 pandemic, with the raised hospitalization of patients and the increased use of antimicrobial agents, boosted the emergence of difficult-to-trea...
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doaj-82b86993725e471da54cd91929149e3a2021-08-26T13:28:01ZengMDPI AGAntibiotics2079-63822021-08-011094294210.3390/antibiotics10080942Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel AntimicrobialsSílvia A. Sousa0Joana R. Feliciano1Tiago Pita2Catarina F. Soeiro3Beatriz L. Mendes4Luis G. Alves5Jorge H. Leitão6Department of Bioengineering, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalDepartment of Bioengineering, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalDepartment of Bioengineering, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalDepartment of Bioengineering, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalDepartment of Bioengineering, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalCentro de Química Estrutural, Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, 1049-003 Lisboa, PortugalDepartment of Bioengineering, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, PortugalNosocomial bacterial infections are associated with high morbidity and mortality, posing a huge burden to healthcare systems worldwide. The ongoing COVID-19 pandemic, with the raised hospitalization of patients and the increased use of antimicrobial agents, boosted the emergence of difficult-to-treat multidrug-resistant (MDR) bacteria in hospital settings. Therefore, current available antibiotic treatments often have limited or no efficacy against nosocomial bacterial infections, and novel therapeutic approaches need to be considered. In this review, we analyze current antibacterial alternatives under investigation, focusing on metal-based complexes, antimicrobial peptides, and antisense antimicrobial therapeutics. The association of new compounds with older, commercially available antibiotics and the repurposing of existing drugs are also revised in this work.https://www.mdpi.com/2079-6382/10/8/942nosocomial infectionsmultidrug-resistant (MDR) bacterianovel antimicrobial agentsdrug repurposingmetal-based complexesantimicrobial peptides |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sílvia A. Sousa Joana R. Feliciano Tiago Pita Catarina F. Soeiro Beatriz L. Mendes Luis G. Alves Jorge H. Leitão |
spellingShingle |
Sílvia A. Sousa Joana R. Feliciano Tiago Pita Catarina F. Soeiro Beatriz L. Mendes Luis G. Alves Jorge H. Leitão Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials Antibiotics nosocomial infections multidrug-resistant (MDR) bacteria novel antimicrobial agents drug repurposing metal-based complexes antimicrobial peptides |
author_facet |
Sílvia A. Sousa Joana R. Feliciano Tiago Pita Catarina F. Soeiro Beatriz L. Mendes Luis G. Alves Jorge H. Leitão |
author_sort |
Sílvia A. Sousa |
title |
Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials |
title_short |
Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials |
title_full |
Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials |
title_fullStr |
Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials |
title_full_unstemmed |
Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials |
title_sort |
bacterial nosocomial infections: multidrug resistance as a trigger for the development of novel antimicrobials |
publisher |
MDPI AG |
series |
Antibiotics |
issn |
2079-6382 |
publishDate |
2021-08-01 |
description |
Nosocomial bacterial infections are associated with high morbidity and mortality, posing a huge burden to healthcare systems worldwide. The ongoing COVID-19 pandemic, with the raised hospitalization of patients and the increased use of antimicrobial agents, boosted the emergence of difficult-to-treat multidrug-resistant (MDR) bacteria in hospital settings. Therefore, current available antibiotic treatments often have limited or no efficacy against nosocomial bacterial infections, and novel therapeutic approaches need to be considered. In this review, we analyze current antibacterial alternatives under investigation, focusing on metal-based complexes, antimicrobial peptides, and antisense antimicrobial therapeutics. The association of new compounds with older, commercially available antibiotics and the repurposing of existing drugs are also revised in this work. |
topic |
nosocomial infections multidrug-resistant (MDR) bacteria novel antimicrobial agents drug repurposing metal-based complexes antimicrobial peptides |
url |
https://www.mdpi.com/2079-6382/10/8/942 |
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