Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study
Aim. The aim of the study was to assess the impact of the long-term use of the composite probiotics in patients after restorative proctocolectomy. Method. Forty-three patients (20 females and 23 males, aged 21 to 68 years) after restorative proctocolectomy were included in the study. After randomiza...
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doaj-82cf39ea661f42e88d8342d99a12511d2020-11-25T00:36:26ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/208064208064Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective StudyBanasiewicz Tomasz0Stojcev Zoran1Walkowiak Jarosław2Marciniak Ryszard3Grochowalski Marcin4Burdyński Robert5Krokowicz Piotr6Krokowicz Lukasz7Paszkowski Jacek8Gronek Piotr9Pyda Przemysław10Drews Michał11Department of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Ulica Przybyszewskiego 49, 60-355 Poznań, PolandRegional Specialist Hospital, Department of General, Vascular and Oncologic Surgery, 76-200 Slupsk, PolandI Chair of Pediatrics, Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, 60-572 Poznań, PolandDepartment of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Ulica Przybyszewskiego 49, 60-355 Poznań, PolandDepartment of General and Colorectal Surgery, Poznan University of Medical Sciences, 61-285 Poznań, PolandDepartment of General and Colorectal Surgery, Poznan University of Medical Sciences, 61-285 Poznań, PolandDepartment of General and Colorectal Surgery, Poznan University of Medical Sciences, 61-285 Poznań, PolandDepartment of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Ulica Przybyszewskiego 49, 60-355 Poznań, PolandDepartment of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Ulica Przybyszewskiego 49, 60-355 Poznań, PolandDepartment of Physiology, University School of Physical Education, 61-871 Poznań, PolandDepartment of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Ulica Przybyszewskiego 49, 60-355 Poznań, PolandDepartment of General Surgery, Oncologic Gastroenterologic Surgery and Plastic Surgery, Poznan University of Medical Sciences, Ulica Przybyszewskiego 49, 60-355 Poznań, PolandAim. The aim of the study was to assess the impact of the long-term use of the composite probiotics in patients after restorative proctocolectomy. Method. Forty-three patients (20 females and 23 males, aged 21 to 68 years) after restorative proctocolectomy were included in the study. After randomization patients were divided into placebo group and treatment group with oral intake of probiotic containing Lactobacillus acidophilus, Lactobacillus delbrueckii subsp. bulgaricus, and Bifidobacterium bifidus. Patients were investigated during initial visit and during final visit after 9 months. All patients were subjected to standard clinical and endoscopic examination with microscopic study of the specimens. Concentrations of calprotectin and pyruvate kinase isoenzyme M2-PK were determined in all cases. Results. The average severity of pouchitis and the number of patients with pouchitis significantly decrease after 9 months of the probiotic taking. The concentrations of calprotectin and pyruvate kinase isoenzyme M2-PK significantly decreased after the therapy. Conclusions. Nine months of the probiotic treatment (Lactobacillus acidophilus, Lactobacillus delbrueckii subsp. bulgaricus, and Bifidobacterium bifidus) reduced the number of patients with pouchitis, decreased the PDAI score, and also decreased the fecal pyruvate kinase and calprotectin. The long-term probiotics use is safe and well accepted and can be an effective method of the pouchitis prevention.http://dx.doi.org/10.1155/2014/208064 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Banasiewicz Tomasz Stojcev Zoran Walkowiak Jarosław Marciniak Ryszard Grochowalski Marcin Burdyński Robert Krokowicz Piotr Krokowicz Lukasz Paszkowski Jacek Gronek Piotr Pyda Przemysław Drews Michał |
spellingShingle |
Banasiewicz Tomasz Stojcev Zoran Walkowiak Jarosław Marciniak Ryszard Grochowalski Marcin Burdyński Robert Krokowicz Piotr Krokowicz Lukasz Paszkowski Jacek Gronek Piotr Pyda Przemysław Drews Michał Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study BioMed Research International |
author_facet |
Banasiewicz Tomasz Stojcev Zoran Walkowiak Jarosław Marciniak Ryszard Grochowalski Marcin Burdyński Robert Krokowicz Piotr Krokowicz Lukasz Paszkowski Jacek Gronek Piotr Pyda Przemysław Drews Michał |
author_sort |
Banasiewicz Tomasz |
title |
Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study |
title_short |
Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study |
title_full |
Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study |
title_fullStr |
Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study |
title_full_unstemmed |
Long-Term Use of Probiotics Lactobacillus and Bifidobacterium Has a Prophylactic Effect on the Occurrence and Severity of Pouchitis: A Randomized Prospective Study |
title_sort |
long-term use of probiotics lactobacillus and bifidobacterium has a prophylactic effect on the occurrence and severity of pouchitis: a randomized prospective study |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Aim. The aim of the study was to assess the impact of the long-term use of the composite probiotics in patients after restorative proctocolectomy. Method. Forty-three patients (20 females and 23 males, aged 21 to 68 years) after restorative proctocolectomy were included in the study. After randomization patients were divided into placebo group and treatment group with oral intake of probiotic containing Lactobacillus acidophilus, Lactobacillus delbrueckii subsp. bulgaricus, and Bifidobacterium bifidus. Patients were investigated during initial visit and during final visit after 9 months. All patients were subjected to standard clinical and endoscopic examination with microscopic study of the specimens. Concentrations of calprotectin and pyruvate kinase isoenzyme M2-PK were determined in all cases. Results. The average severity of pouchitis and the number of patients with pouchitis significantly decrease after 9 months of the probiotic taking. The concentrations of calprotectin and pyruvate kinase isoenzyme M2-PK significantly decreased after the therapy. Conclusions. Nine months of the probiotic treatment (Lactobacillus acidophilus, Lactobacillus delbrueckii subsp. bulgaricus, and Bifidobacterium bifidus) reduced the number of patients with pouchitis, decreased the PDAI score, and also decreased the fecal pyruvate kinase and calprotectin. The long-term probiotics use is safe and well accepted and can be an effective method of the pouchitis prevention. |
url |
http://dx.doi.org/10.1155/2014/208064 |
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