Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology
Tendon harbors a cell population that possesses stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon stem/progenitor cells (TSPCs). Various techniques have been employed to study how TSPCs are implicated in tendon development, homeos...
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doaj-82cfc4d1073749e6a04c071a04d923662021-02-18T07:12:49ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-02-01910.3389/fcell.2021.631272631272Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon BiologyZizhan Huang0Zizhan Huang1Zizhan Huang2Zi Yin3Zi Yin4Zi Yin5Jialu Xu6Yang Fei7Yang Fei8Yang Fei9Boon Chin Heng10Xuesheng Jiang11Weishan Chen12Weishan Chen13Weiliang Shen14Weiliang Shen15Weiliang Shen16Weiliang Shen17Weiliang Shen18Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaOrthopedics Research Institute, Zhejiang University, Hangzhou, ChinaInstitute of Sports Medicine, Zhejiang University, Hangzhou, ChinaInstitute of Sports Medicine, Zhejiang University, Hangzhou, ChinaDr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, ChinaChina Orthopedic Regenerative Medicine (CORMed), Hangzhou, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaOrthopedics Research Institute, Zhejiang University, Hangzhou, ChinaInstitute of Sports Medicine, Zhejiang University, Hangzhou, ChinaSchool of Stomatology, Peking University, Beijing, ChinaDepartment of Orthopedic Surgery, Huzhou Hospital, Zhejiang University, Huzhou, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaOrthopedics Research Institute, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaOrthopedics Research Institute, Zhejiang University, Hangzhou, ChinaInstitute of Sports Medicine, Zhejiang University, Hangzhou, ChinaDr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, ChinaChina Orthopedic Regenerative Medicine (CORMed), Hangzhou, ChinaTendon harbors a cell population that possesses stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon stem/progenitor cells (TSPCs). Various techniques have been employed to study how TSPCs are implicated in tendon development, homeostasis and healing. Recent advances in single-cell analysis have enabled much progress in identifying and characterizing distinct subpopulations of TSPCs, which provides a more comprehensive view of TSPCs function in tendon biology. Understanding the mechanisms of physiological and pathological processes regulated by TSPCs, especially a particular subpopulation, would greatly benefit treatment of diseased tendons. Here, we summarize the current scientific literature on the various subpopulations of TSPCs, and discuss how TSPCs can contribute to tissue homeostasis and pathogenesis, as well as examine the key modulatory signaling pathways that determine stem/progenitor cell state. A better understanding of the roles that TSPCs play in tendon biology may facilitate the development of novel treatment strategies for tendon diseases.https://www.frontiersin.org/articles/10.3389/fcell.2021.631272/fulltendon stem/progenitor cellssubpopulationnichehealingTGFβ |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zizhan Huang Zizhan Huang Zizhan Huang Zi Yin Zi Yin Zi Yin Jialu Xu Yang Fei Yang Fei Yang Fei Boon Chin Heng Xuesheng Jiang Weishan Chen Weishan Chen Weiliang Shen Weiliang Shen Weiliang Shen Weiliang Shen Weiliang Shen |
spellingShingle |
Zizhan Huang Zizhan Huang Zizhan Huang Zi Yin Zi Yin Zi Yin Jialu Xu Yang Fei Yang Fei Yang Fei Boon Chin Heng Xuesheng Jiang Weishan Chen Weishan Chen Weiliang Shen Weiliang Shen Weiliang Shen Weiliang Shen Weiliang Shen Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology Frontiers in Cell and Developmental Biology tendon stem/progenitor cells subpopulation niche healing TGFβ |
author_facet |
Zizhan Huang Zizhan Huang Zizhan Huang Zi Yin Zi Yin Zi Yin Jialu Xu Yang Fei Yang Fei Yang Fei Boon Chin Heng Xuesheng Jiang Weishan Chen Weishan Chen Weiliang Shen Weiliang Shen Weiliang Shen Weiliang Shen Weiliang Shen |
author_sort |
Zizhan Huang |
title |
Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology |
title_short |
Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology |
title_full |
Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology |
title_fullStr |
Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology |
title_full_unstemmed |
Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology |
title_sort |
tendon stem/progenitor cell subpopulations and their implications in tendon biology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-02-01 |
description |
Tendon harbors a cell population that possesses stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon stem/progenitor cells (TSPCs). Various techniques have been employed to study how TSPCs are implicated in tendon development, homeostasis and healing. Recent advances in single-cell analysis have enabled much progress in identifying and characterizing distinct subpopulations of TSPCs, which provides a more comprehensive view of TSPCs function in tendon biology. Understanding the mechanisms of physiological and pathological processes regulated by TSPCs, especially a particular subpopulation, would greatly benefit treatment of diseased tendons. Here, we summarize the current scientific literature on the various subpopulations of TSPCs, and discuss how TSPCs can contribute to tissue homeostasis and pathogenesis, as well as examine the key modulatory signaling pathways that determine stem/progenitor cell state. A better understanding of the roles that TSPCs play in tendon biology may facilitate the development of novel treatment strategies for tendon diseases. |
topic |
tendon stem/progenitor cells subpopulation niche healing TGFβ |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.631272/full |
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