Dynamin 1 regulates amyloid generation through modulation of BACE-1.
BACKGROUND: Several lines of investigation support the notion that endocytosis is crucial for Alzheimer's disease (AD) pathogenesis. Substantial evidence have already been reported regarding the mechanisms underlying amyloid precursor protein (APP) traffic, but the regulation of beta-site APP-C...
Main Authors: | Li Zhu, Meng Su, Louise Lucast, Lijuan Liu, William J Netzer, Samuel E Gandy, Dongming Cai |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3443198?pdf=render |
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