Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples
In this study, the electrochemical behaviors of cephalexin and cefazoline on disposable pencil graphite electrode were investigated in phosphate buffer at pH of 4.5 to 6.0 by differential pulse voltammetry. Sample analysis was performed in phosphate buffer at the optimum medium determined for each...
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Turkish Chemical Society
2019-06-01
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doaj-82e18e0ca4bb4135afa208720afa45f92020-11-25T00:35:15ZengTurkish Chemical SocietyJournal of the Turkish Chemical Society, Section A: Chemistry2149-01202019-06-016221722410.18596/jotcsa.469028Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological SamplesSabriye Perçin ÖzkorucukluBesnik Uka Gizem Yıldırım Baştemur In this study, the electrochemical behaviors of cephalexin and cefazoline on disposable pencil graphite electrode were investigated in phosphate buffer at pH of 4.5 to 6.0 by differential pulse voltammetry. Sample analysis was performed in phosphate buffer at the optimum medium determined for each sample. Validation parameters were studied to show the correctness, sensitivity, and consistency of the method developed for the cephalosporins. It was concluded that disposable pencil graphite electrode could be used effectively in the determination of cephalosporins. The limits of detection (S/N=3) were found to be 0.115 mM and 0.303 mM, for cephalexin and cefazoline, respectively. The analysis of these compounds in pharmaceutical formulations and biological samples was carried out at defined optimum conditions. The recovery values were around 100%. https://dergipark.org.tr/jotcsa/issue/43285/469028electrochemical biosensorspencil graphite electrodevoltammetric methodsBeta-lactam antibiotics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sabriye Perçin Özkorucuklu Besnik Uka Gizem Yıldırım Baştemur |
spellingShingle |
Sabriye Perçin Özkorucuklu Besnik Uka Gizem Yıldırım Baştemur Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples Journal of the Turkish Chemical Society, Section A: Chemistry electrochemical biosensors pencil graphite electrode voltammetric methods Beta-lactam antibiotics |
author_facet |
Sabriye Perçin Özkorucuklu Besnik Uka Gizem Yıldırım Baştemur |
author_sort |
Sabriye Perçin Özkorucuklu |
title |
Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples |
title_short |
Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples |
title_full |
Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples |
title_fullStr |
Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples |
title_full_unstemmed |
Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples |
title_sort |
voltammetric analysis of cephalexin and cefazoline in pharmaceutical formulation and biological samples |
publisher |
Turkish Chemical Society |
series |
Journal of the Turkish Chemical Society, Section A: Chemistry |
issn |
2149-0120 |
publishDate |
2019-06-01 |
description |
In this study, the electrochemical behaviors of cephalexin and cefazoline on disposable pencil graphite electrode were investigated in phosphate buffer at pH of 4.5 to 6.0 by differential pulse voltammetry. Sample analysis was performed in phosphate buffer at the optimum medium determined for each sample. Validation parameters were studied to show the correctness, sensitivity, and consistency of the method developed for the cephalosporins. It was concluded that disposable pencil graphite electrode could be used effectively in the determination of cephalosporins. The limits of detection (S/N=3) were found to be 0.115 mM and 0.303 mM, for cephalexin and cefazoline, respectively. The analysis of these compounds in pharmaceutical formulations and biological samples was carried out at defined optimum conditions. The recovery values were around 100%. |
topic |
electrochemical biosensors pencil graphite electrode voltammetric methods Beta-lactam antibiotics |
url |
https://dergipark.org.tr/jotcsa/issue/43285/469028 |
work_keys_str_mv |
AT sabriyepercinozkorucuklu voltammetricanalysisofcephalexinandcefazolineinpharmaceuticalformulationandbiologicalsamples AT besnikuka voltammetricanalysisofcephalexinandcefazolineinpharmaceuticalformulationandbiologicalsamples AT gizemyıldırımbastemur voltammetricanalysisofcephalexinandcefazolineinpharmaceuticalformulationandbiologicalsamples |
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