EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives
Gastric cancer is the fifth most common malignant tumor and second leading cause of cancer-related deaths worldwide. With the improved understanding of gastric cancer, a subset of gastric cancer patients infected with Epstein–Barr virus (EBV) has been identified. EBV-positive gastric cancer is a typ...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-12-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.583463/full |
id |
doaj-82e48d4e539c4357a9673afd4e082a4a |
---|---|
record_format |
Article |
spelling |
doaj-82e48d4e539c4357a9673afd4e082a4a2020-12-14T19:15:00ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.583463583463EBV-Positive Gastric Cancer: Current Knowledge and Future PerspectivesKeran Sun0Keqi Jia1Huifang Lv2Sai-Qi Wang3Yan Wu4Huijun Lei5Xiaobing Chen6Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Pathology, Pathology Department of Hebei Medical University, Shijiazhuang, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaGastric cancer is the fifth most common malignant tumor and second leading cause of cancer-related deaths worldwide. With the improved understanding of gastric cancer, a subset of gastric cancer patients infected with Epstein–Barr virus (EBV) has been identified. EBV-positive gastric cancer is a type of tumor with unique genomic aberrations, significant clinicopathological features, and a good prognosis. After EBV infects the human body, it first enters an incubation period in which the virus integrates its DNA into the host and expresses the latent protein and then affects DNA methylation through miRNA under the action of the latent protein, which leads to the occurrence of EBV-positive gastric cancer. With recent developments in immunotherapy, better treatment of EBV-positive gastric cancer patients appears achievable. Moreover, studies show that treatment with immunotherapy has a high effective rate in patients with EBV-positive gastric cancer. This review summarizes the research status of EBV-positive gastric cancer in recent years and indicates areas for improvement of clinical practice.https://www.frontiersin.org/articles/10.3389/fonc.2020.583463/fullEpstein–Barr virusgastric cancermiRNADNA methylationimmune checkpoint |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keran Sun Keqi Jia Huifang Lv Sai-Qi Wang Yan Wu Huijun Lei Xiaobing Chen |
spellingShingle |
Keran Sun Keqi Jia Huifang Lv Sai-Qi Wang Yan Wu Huijun Lei Xiaobing Chen EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives Frontiers in Oncology Epstein–Barr virus gastric cancer miRNA DNA methylation immune checkpoint |
author_facet |
Keran Sun Keqi Jia Huifang Lv Sai-Qi Wang Yan Wu Huijun Lei Xiaobing Chen |
author_sort |
Keran Sun |
title |
EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives |
title_short |
EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives |
title_full |
EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives |
title_fullStr |
EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives |
title_full_unstemmed |
EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives |
title_sort |
ebv-positive gastric cancer: current knowledge and future perspectives |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-12-01 |
description |
Gastric cancer is the fifth most common malignant tumor and second leading cause of cancer-related deaths worldwide. With the improved understanding of gastric cancer, a subset of gastric cancer patients infected with Epstein–Barr virus (EBV) has been identified. EBV-positive gastric cancer is a type of tumor with unique genomic aberrations, significant clinicopathological features, and a good prognosis. After EBV infects the human body, it first enters an incubation period in which the virus integrates its DNA into the host and expresses the latent protein and then affects DNA methylation through miRNA under the action of the latent protein, which leads to the occurrence of EBV-positive gastric cancer. With recent developments in immunotherapy, better treatment of EBV-positive gastric cancer patients appears achievable. Moreover, studies show that treatment with immunotherapy has a high effective rate in patients with EBV-positive gastric cancer. This review summarizes the research status of EBV-positive gastric cancer in recent years and indicates areas for improvement of clinical practice. |
topic |
Epstein–Barr virus gastric cancer miRNA DNA methylation immune checkpoint |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.583463/full |
work_keys_str_mv |
AT keransun ebvpositivegastriccancercurrentknowledgeandfutureperspectives AT keqijia ebvpositivegastriccancercurrentknowledgeandfutureperspectives AT huifanglv ebvpositivegastriccancercurrentknowledgeandfutureperspectives AT saiqiwang ebvpositivegastriccancercurrentknowledgeandfutureperspectives AT yanwu ebvpositivegastriccancercurrentknowledgeandfutureperspectives AT huijunlei ebvpositivegastriccancercurrentknowledgeandfutureperspectives AT xiaobingchen ebvpositivegastriccancercurrentknowledgeandfutureperspectives |
_version_ |
1724383363655008256 |