Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.

Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.

Renal ischemia-reperfusion (IR) injury (IRI) is a common and important trigger of acute renal injury (AKI). It is inevitably linked to transplantation. Involving both, the innate and the adaptive immune response, IRI causes subsequent sterile inflammation. Attraction to and transmigration of immune...

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Bibliographic Details
Main Authors: Dominik Kentrup, Stefan Reuter, Uta Schnöckel, Alexander Grabner, Bayram Edemir, Hermann Pavenstädt, Otmar Schober, Michael Schäfers, Eberhard Schlatter, Eckhart Büssemaker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3198766?pdf=render

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