Pathophysiology of Cerebral Edema—A Comprehensive Review

Cerebral edema is a condition where an excess of cerebral water accumulates due to primary neurological or non-neurological causes. Cerebral edema complicates many brain pathologies causing additional injury often in excess of the original neurological insult. Classic descriptions divide cerebral ed...

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Main Authors:	Tara Dalby, Elyana Wohl, Michael Dinsmore, Zoe Unger, Tumul Chowdhury, Lakshmikumar Venkatraghavan
Format:	Article
Language:	English
Published:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2020-12-01
Series:	Journal of Neuroanaesthesiology and Critical Care
Subjects:	cerebral edema blood–brain barrier aquaporins
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1721165

id	doaj-82ef7fb46b96459f8b269da41c7327e6
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spelling	doaj-82ef7fb46b96459f8b269da41c7327e62020-12-04T00:00:19ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Neuroanaesthesiology and Critical Care2348-05482348-926X2020-12-0110.1055/s-0040-1721165Pathophysiology of Cerebral Edema—A Comprehensive ReviewTara Dalby0Elyana Wohl1Michael Dinsmore2Zoe Unger3Tumul Chowdhury4Lakshmikumar Venkatraghavan5Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, CanadaDepartment of Anesthesia, Notre-Dame Hospital, Montreal, Quebec, CanadaDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, CanadaDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, CanadaDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, CanadaDepartment of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, CanadaCerebral edema is a condition where an excess of cerebral water accumulates due to primary neurological or non-neurological causes. Cerebral edema complicates many brain pathologies causing additional injury often in excess of the original neurological insult. Classic descriptions divide cerebral edema into cytotoxic, vasogenic, interstitial, and osmotic subtypes. The interplay of different mechanisms is important in the clinical manifestations. Recent research has advanced our understanding of the molecular pathophysiology of cerebral edema, exposing the central role of aquaporins and specific ion channels. The aim of this review is to provide a comprehensive overview of the molecular pathophysiology of cerebral edema including unique disease specific mechanisms.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1721165cerebral edemablood–brain barrieraquaporins
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tara Dalby Elyana Wohl Michael Dinsmore Zoe Unger Tumul Chowdhury Lakshmikumar Venkatraghavan
spellingShingle	Tara Dalby Elyana Wohl Michael Dinsmore Zoe Unger Tumul Chowdhury Lakshmikumar Venkatraghavan Pathophysiology of Cerebral Edema—A Comprehensive Review Journal of Neuroanaesthesiology and Critical Care cerebral edema blood–brain barrier aquaporins
author_facet	Tara Dalby Elyana Wohl Michael Dinsmore Zoe Unger Tumul Chowdhury Lakshmikumar Venkatraghavan
author_sort	Tara Dalby
title	Pathophysiology of Cerebral Edema—A Comprehensive Review
title_short	Pathophysiology of Cerebral Edema—A Comprehensive Review
title_full	Pathophysiology of Cerebral Edema—A Comprehensive Review
title_fullStr	Pathophysiology of Cerebral Edema—A Comprehensive Review
title_full_unstemmed	Pathophysiology of Cerebral Edema—A Comprehensive Review
title_sort	pathophysiology of cerebral edema—a comprehensive review
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
series	Journal of Neuroanaesthesiology and Critical Care
issn	2348-0548 2348-926X
publishDate	2020-12-01
description	Cerebral edema is a condition where an excess of cerebral water accumulates due to primary neurological or non-neurological causes. Cerebral edema complicates many brain pathologies causing additional injury often in excess of the original neurological insult. Classic descriptions divide cerebral edema into cytotoxic, vasogenic, interstitial, and osmotic subtypes. The interplay of different mechanisms is important in the clinical manifestations. Recent research has advanced our understanding of the molecular pathophysiology of cerebral edema, exposing the central role of aquaporins and specific ion channels. The aim of this review is to provide a comprehensive overview of the molecular pathophysiology of cerebral edema including unique disease specific mechanisms.
topic	cerebral edema blood–brain barrier aquaporins
url	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1721165
work_keys_str_mv	AT taradalby pathophysiologyofcerebraledemaacomprehensivereview AT elyanawohl pathophysiologyofcerebraledemaacomprehensivereview AT michaeldinsmore pathophysiologyofcerebraledemaacomprehensivereview AT zoeunger pathophysiologyofcerebraledemaacomprehensivereview AT tumulchowdhury pathophysiologyofcerebraledemaacomprehensivereview AT lakshmikumarvenkatraghavan pathophysiologyofcerebraledemaacomprehensivereview
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Pathophysiology of Cerebral Edema—A Comprehensive Review

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