Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
Leishmania infection consists in two sequential events, the host cell colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted antigens. The i...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2007-01-01
|
Series: | Journal of Biomedicine and Biotechnology |
Online Access: | http://dx.doi.org/10.1155/2007/85154 |
Summary: | Leishmania infection consists in two sequential events, the host cell
colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss
the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted
antigens. The importance of the immune response against secreted and surface antigens is
noted in the establishment of the infection and we dissect the contribution of the nonsecreted
antigens in the immunopathology associated with leishmaniasis, showing the importance of these
panantigens during the course of the infection. As a further example of proteins belonging to these
two different groups, we include several laboratorial observations on Leishmania
Sir2 and LicTXNPx as excreted/secreted proteins and LmS3arp
and
LimTXNPx as nonsecreted/panantigens. The role of these two groups of antigens
in the immune response observed during the infection is discussed. |
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ISSN: | 1110-7243 1110-7251 |