Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens
Leishmania infection consists in two sequential events, the host cell colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted antigens. The i...
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doaj-82f5e1b8e290414bb6f8a1c5cdb6e59f2020-11-24T22:09:54ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512007-01-01200710.1155/2007/8515485154Immune Response Regulation by Leishmania Secreted and Nonsecreted AntigensNuno Santarém0Ricardo Silvestre1Joana Tavares2Marta Silva3Sofia Cabral4Joana Maciel5Anabela Cordeiro-da-Silva6Departamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, PortugalDepartamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, PortugalDepartamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, PortugalDepartamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, PortugalDepartamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, PortugalDepartamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, PortugalDepartamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, Porto 4099-030, PortugalLeishmania infection consists in two sequential events, the host cell colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted antigens. The importance of the immune response against secreted and surface antigens is noted in the establishment of the infection and we dissect the contribution of the nonsecreted antigens in the immunopathology associated with leishmaniasis, showing the importance of these panantigens during the course of the infection. As a further example of proteins belonging to these two different groups, we include several laboratorial observations on Leishmania Sir2 and LicTXNPx as excreted/secreted proteins and LmS3arp and LimTXNPx as nonsecreted/panantigens. The role of these two groups of antigens in the immune response observed during the infection is discussed.http://dx.doi.org/10.1155/2007/85154 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nuno Santarém Ricardo Silvestre Joana Tavares Marta Silva Sofia Cabral Joana Maciel Anabela Cordeiro-da-Silva |
spellingShingle |
Nuno Santarém Ricardo Silvestre Joana Tavares Marta Silva Sofia Cabral Joana Maciel Anabela Cordeiro-da-Silva Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens Journal of Biomedicine and Biotechnology |
author_facet |
Nuno Santarém Ricardo Silvestre Joana Tavares Marta Silva Sofia Cabral Joana Maciel Anabela Cordeiro-da-Silva |
author_sort |
Nuno Santarém |
title |
Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens |
title_short |
Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens |
title_full |
Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens |
title_fullStr |
Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens |
title_full_unstemmed |
Immune Response Regulation by Leishmania Secreted and Nonsecreted Antigens |
title_sort |
immune response regulation by leishmania secreted and nonsecreted antigens |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2007-01-01 |
description |
Leishmania infection consists in two sequential events, the host cell
colonization followed by the proliferation/dissemination of the parasite. In this review, we discuss
the importance of two distinct sets of molecules, the secreted and/or surface and the nonsecreted
antigens. The importance of the immune response against secreted and surface antigens is
noted in the establishment of the infection and we dissect the contribution of the nonsecreted
antigens in the immunopathology associated with leishmaniasis, showing the importance of these
panantigens during the course of the infection. As a further example of proteins belonging to these
two different groups, we include several laboratorial observations on Leishmania
Sir2 and LicTXNPx as excreted/secreted proteins and LmS3arp
and
LimTXNPx as nonsecreted/panantigens. The role of these two groups of antigens
in the immune response observed during the infection is discussed. |
url |
http://dx.doi.org/10.1155/2007/85154 |
work_keys_str_mv |
AT nunosantarem immuneresponseregulationbyleishmaniasecretedandnonsecretedantigens AT ricardosilvestre immuneresponseregulationbyleishmaniasecretedandnonsecretedantigens AT joanatavares immuneresponseregulationbyleishmaniasecretedandnonsecretedantigens AT martasilva immuneresponseregulationbyleishmaniasecretedandnonsecretedantigens AT sofiacabral immuneresponseregulationbyleishmaniasecretedandnonsecretedantigens AT joanamaciel immuneresponseregulationbyleishmaniasecretedandnonsecretedantigens AT anabelacordeirodasilva immuneresponseregulationbyleishmaniasecretedandnonsecretedantigens |
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