Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of <i>Chelidonium majus</i> L. by LC–MS/MS

Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of <i>Chelidonium majus</i> L. by LC–MS/MS

A novel strategy was developed to identify hepatotoxic compounds in traditional Chinese medicines (TCMs). It is based on the exposure of HL-7702 cells to a TCM extract, followed by the identification and further determination of potential hepatotoxic compounds accumulated in the cells by liquid chro...

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Bibliographic Details
Main Authors: Cuiting Wu, Xin Wang, Ming Xu, Youping Liu, Xin Di
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
intracellular accumulation
LC–MS/MS
alkaloids
hepatotoxicity
<i>Chelidonium majus</i> L.
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/24/13/2410

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