Genome-Environmental Risk Assessment of Cocaine Dependence
Cocaine-associated biomedical and psychosocial problems are substantial 21st century global burdens of disease. This burden is largely driven by a cocaine dependence process that becomes engaged with increasing occasions of cocaine product use. For this reason, the development of a risk prediction m...
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2012-05-01
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doaj-82fb15dc42c14c4d8b261f5fc81cbf722020-11-24T23:15:58ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-05-01310.3389/fgene.2012.0008324141Genome-Environmental Risk Assessment of Cocaine DependenceChangshuai eWei0James C Anthony1Qing eLu2Michigan State UniversityMichigan State UniversityMichigan State UniversityCocaine-associated biomedical and psychosocial problems are substantial 21st century global burdens of disease. This burden is largely driven by a cocaine dependence process that becomes engaged with increasing occasions of cocaine product use. For this reason, the development of a risk prediction model for cocaine dependence may be of special value. Ultimately, success in building such a risk prediction model may help promote personalized cocaine dependence prediction, prevention, and treatment approaches not presently available. As an initial step toward this goal, we conducted a genome-environmental risk prediction study for cocaine dependence, simultaneously considering 948,658 single nucleotide polymorphisms (SNPs), six potentially cocaine-related facets of environment, and three personal characteristics. In this study, a novel statistical approach was applied to 1045 case-control samples from the Family Study of Cocaine Dependence. The results identify 330 low- to medium-effect size SNPs (i.e., those with a single locus p-value of less than 10-4) that made a substantial contribution to cocaine dependence risk prediction (AUC=0.718). Inclusion of six facets of environment and three personal characteristics yielded greater accuracy (AUC=0.809). Of special importance was childhood abuse (CA) among trauma experiences, with a potentially important interaction of CA and the GBE1 gene in cocaine dependence risk prediction. Genome-environmental risk prediction models may become more promising in future risk prediction research, once a more substantial array of environmental facets are taken into account, sometimes with model improvement when gene-by-environment product terms are included as part of these risk predication models.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00083/fullcocaine dependencegenome-environmental risk predictionchildhood abuseGBE1 genetree-assembling ROC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Changshuai eWei James C Anthony Qing eLu |
spellingShingle |
Changshuai eWei James C Anthony Qing eLu Genome-Environmental Risk Assessment of Cocaine Dependence Frontiers in Genetics cocaine dependence genome-environmental risk prediction childhood abuse GBE1 gene tree-assembling ROC |
author_facet |
Changshuai eWei James C Anthony Qing eLu |
author_sort |
Changshuai eWei |
title |
Genome-Environmental Risk Assessment of Cocaine Dependence |
title_short |
Genome-Environmental Risk Assessment of Cocaine Dependence |
title_full |
Genome-Environmental Risk Assessment of Cocaine Dependence |
title_fullStr |
Genome-Environmental Risk Assessment of Cocaine Dependence |
title_full_unstemmed |
Genome-Environmental Risk Assessment of Cocaine Dependence |
title_sort |
genome-environmental risk assessment of cocaine dependence |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2012-05-01 |
description |
Cocaine-associated biomedical and psychosocial problems are substantial 21st century global burdens of disease. This burden is largely driven by a cocaine dependence process that becomes engaged with increasing occasions of cocaine product use. For this reason, the development of a risk prediction model for cocaine dependence may be of special value. Ultimately, success in building such a risk prediction model may help promote personalized cocaine dependence prediction, prevention, and treatment approaches not presently available. As an initial step toward this goal, we conducted a genome-environmental risk prediction study for cocaine dependence, simultaneously considering 948,658 single nucleotide polymorphisms (SNPs), six potentially cocaine-related facets of environment, and three personal characteristics. In this study, a novel statistical approach was applied to 1045 case-control samples from the Family Study of Cocaine Dependence. The results identify 330 low- to medium-effect size SNPs (i.e., those with a single locus p-value of less than 10-4) that made a substantial contribution to cocaine dependence risk prediction (AUC=0.718). Inclusion of six facets of environment and three personal characteristics yielded greater accuracy (AUC=0.809). Of special importance was childhood abuse (CA) among trauma experiences, with a potentially important interaction of CA and the GBE1 gene in cocaine dependence risk prediction. Genome-environmental risk prediction models may become more promising in future risk prediction research, once a more substantial array of environmental facets are taken into account, sometimes with model improvement when gene-by-environment product terms are included as part of these risk predication models. |
topic |
cocaine dependence genome-environmental risk prediction childhood abuse GBE1 gene tree-assembling ROC |
url |
http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00083/full |
work_keys_str_mv |
AT changshuaiewei genomeenvironmentalriskassessmentofcocainedependence AT jamescanthony genomeenvironmentalriskassessmentofcocainedependence AT qingelu genomeenvironmentalriskassessmentofcocainedependence |
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1725588647767441408 |