Study of gastrointestinal stromal tumors with c-kit immunostaining
<p><strong>Background: </strong>Mutation of the C-KIT oncogene is the central event in gastrointestinal stromal tumors which are the most common mesenchymal tumors arising from the tubular gastrointestinal tract.</p> <p><strong>Materials and Methods: </strong&g...
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doaj-8301a413010d405289de84cebff097172020-11-25T01:28:27ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082011-03-0111414410.3126/jpn.v1i1.44503688Study of gastrointestinal stromal tumors with c-kit immunostainingB Sigdel0S Vaidya1Sabira KC2Department of Pathology, Patan Academy of Health Sciences, School of MedicineDepartment of Pathology, Patan Academy of Health Sciences, School of MedicineDepartment of Pathology, Patan Academy of Health Sciences, School of Medicine<p><strong>Background: </strong>Mutation of the C-KIT oncogene is the central event in gastrointestinal stromal tumors which are the most common mesenchymal tumors arising from the tubular gastrointestinal tract.</p> <p><strong>Materials and Methods: </strong>A study was conducted in Patan hospital from April 2003 to May 2010. Mesenchymal tumors arising from the tubular gastrointestinal tract with the microscopic features suggesting gastrointestinal stromal tumor were included in the study.</p> <p><strong>Results: </strong>A total of 22 cases were studied. The incidence was highest amongst the older age group (86.36%), than in younger people (13.63%). The tumor most commonly involved the small intestine (54.54%), followed by the stomach (36.36%). Most (59.09%) of the tumors were of huge size measuring >100 mm, and showed necrosis, hemorrhage and cystic degeneration. Mitotic activity was high (>5/50 high power fields) in 55% of the cases.</p> <p><strong>Conclusion: </strong>C-KIT immunostaining showed positivity in 19 (86.36%) of the tumors in this study. Mutation of the C-KIT oncogene is seen in most of the gastrointestinal stromal tumors.<strong> </strong></p> <p><strong>Keywords: </strong>Gastrointestinal; Stromal tumors; C-KIT oncogene</p> <p>DOI: 10.3126/jpn.v1i1.4450</p> <p><em>Journal of Pathology of Nepal </em>(2011) Vol.1, 41-44</p>http://www.nepjol.info/index.php/JPN/article/view/4450GastrointestinalStromal tumorsC-KIT oncogene |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
B Sigdel S Vaidya Sabira KC |
spellingShingle |
B Sigdel S Vaidya Sabira KC Study of gastrointestinal stromal tumors with c-kit immunostaining Journal of Pathology of Nepal Gastrointestinal Stromal tumors C-KIT oncogene |
author_facet |
B Sigdel S Vaidya Sabira KC |
author_sort |
B Sigdel |
title |
Study of gastrointestinal stromal tumors with c-kit immunostaining |
title_short |
Study of gastrointestinal stromal tumors with c-kit immunostaining |
title_full |
Study of gastrointestinal stromal tumors with c-kit immunostaining |
title_fullStr |
Study of gastrointestinal stromal tumors with c-kit immunostaining |
title_full_unstemmed |
Study of gastrointestinal stromal tumors with c-kit immunostaining |
title_sort |
study of gastrointestinal stromal tumors with c-kit immunostaining |
publisher |
Association of Clinical Pathologists of Nepal |
series |
Journal of Pathology of Nepal |
issn |
2091-0797 2091-0908 |
publishDate |
2011-03-01 |
description |
<p><strong>Background: </strong>Mutation of the C-KIT oncogene is the central event in gastrointestinal stromal tumors which are the most common mesenchymal tumors arising from the tubular gastrointestinal tract.</p> <p><strong>Materials and Methods: </strong>A study was conducted in Patan hospital from April 2003 to May 2010. Mesenchymal tumors arising from the tubular gastrointestinal tract with the microscopic features suggesting gastrointestinal stromal tumor were included in the study.</p> <p><strong>Results: </strong>A total of 22 cases were studied. The incidence was highest amongst the older age group (86.36%), than in younger people (13.63%). The tumor most commonly involved the small intestine (54.54%), followed by the stomach (36.36%). Most (59.09%) of the tumors were of huge size measuring >100 mm, and showed necrosis, hemorrhage and cystic degeneration. Mitotic activity was high (>5/50 high power fields) in 55% of the cases.</p> <p><strong>Conclusion: </strong>C-KIT immunostaining showed positivity in 19 (86.36%) of the tumors in this study. Mutation of the C-KIT oncogene is seen in most of the gastrointestinal stromal tumors.<strong> </strong></p> <p><strong>Keywords: </strong>Gastrointestinal; Stromal tumors; C-KIT oncogene</p> <p>DOI: 10.3126/jpn.v1i1.4450</p> <p><em>Journal of Pathology of Nepal </em>(2011) Vol.1, 41-44</p> |
topic |
Gastrointestinal Stromal tumors C-KIT oncogene |
url |
http://www.nepjol.info/index.php/JPN/article/view/4450 |
work_keys_str_mv |
AT bsigdel studyofgastrointestinalstromaltumorswithckitimmunostaining AT svaidya studyofgastrointestinalstromaltumorswithckitimmunostaining AT sabirakc studyofgastrointestinalstromaltumorswithckitimmunostaining |
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