Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis
Background: In dural venous sinus thrombosis (DVST), the mortality ranges 5–30%. Deep venous system involvement and septic dural sinus thrombosis have a higher mortality rate. In acute occlusion, collateral flow may not be established, which may result in significant edema and mass effect. Endovascu...
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doaj-8309364d491d47079a2f562bb01062f02021-07-28T00:14:12ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Radiology and Imaging0971-30261998-38082017-01-012701828710.4103/0971-3026.202956Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosisSuraj Mammen0Shyamkumar Nidugala Keshava1Vinu Moses2Sanjith Aaron3Munawwar Ahmed4George K Chiramel5Sunithi E Mani6Mathew Alexander7Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Radiology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Radiology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Radiology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Radiology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Radiology, Christian Medical College, Vellore, Tamil Nadu, IndiaDepartment of Neurology, Christian Medical College, Vellore, Tamil Nadu, IndiaBackground: In dural venous sinus thrombosis (DVST), the mortality ranges 5–30%. Deep venous system involvement and septic dural sinus thrombosis have a higher mortality rate. In acute occlusion, collateral flow may not be established, which may result in significant edema and mass effect. Endovascular interventions may be considered as a treatment option in appropriate high-risk patients with DVST. Materials and Methods: Eight patients with magnetic resonance imaging (MRI)-confirmed dural sinus thrombosis, who did not respond to the conventional standard medical treatment, were subsequently treated with mechanical thrombectomy using the Penumbra System®. In all cases, medical treatment including anticoagulants were continued following the procedure for a minimum period of 1 year. Results: Recanalization of the dural sinus thrombosis was achieved in all 8 cases. There were no immediate or late endovascular-related complications. One death occurred due to an unrelated medical event. At 6 months, there was notable improvement in the modified Rankin Score (mRS), with 5/8 (62%) patients achieving mRS of 2 or less. The follow-up ranged between 3 months and 26 months (mean: 14.5 months), and there were no new neurological events during the follow-up period. Conclusion: Cerebral venous sinus thrombosis is a rare but life-threatening condition that demands timely diagnosis and therapy. In cases of rapidly declining neurological status despite standard therapy with systemic anticoagulation and anti-edema measures, mechanical thrombectomy could be a lifesaving and effective option. In this study, good outcomes were observed in the majority of patients at long-term follow up.http://www.thieme-connect.de/DOI/DOI?10.4103/0971-3026.202956dural sinus thrombosisneurointerventionrecanalizationthrombectomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suraj Mammen Shyamkumar Nidugala Keshava Vinu Moses Sanjith Aaron Munawwar Ahmed George K Chiramel Sunithi E Mani Mathew Alexander |
spellingShingle |
Suraj Mammen Shyamkumar Nidugala Keshava Vinu Moses Sanjith Aaron Munawwar Ahmed George K Chiramel Sunithi E Mani Mathew Alexander Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis Indian Journal of Radiology and Imaging dural sinus thrombosis neurointervention recanalization thrombectomy |
author_facet |
Suraj Mammen Shyamkumar Nidugala Keshava Vinu Moses Sanjith Aaron Munawwar Ahmed George K Chiramel Sunithi E Mani Mathew Alexander |
author_sort |
Suraj Mammen |
title |
Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis |
title_short |
Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis |
title_full |
Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis |
title_fullStr |
Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis |
title_full_unstemmed |
Role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis |
title_sort |
role of penumbra mechanical thrombectomy device in acute dural sinus thrombosis |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
Indian Journal of Radiology and Imaging |
issn |
0971-3026 1998-3808 |
publishDate |
2017-01-01 |
description |
Background: In dural venous sinus thrombosis (DVST), the mortality ranges 5–30%. Deep venous system involvement and septic dural sinus thrombosis have a higher mortality rate. In acute occlusion, collateral flow may not be established, which may result in significant edema and mass effect. Endovascular interventions may be considered as a treatment option in appropriate high-risk patients with DVST. Materials and Methods: Eight patients with magnetic resonance imaging (MRI)-confirmed dural sinus thrombosis, who did not respond to the conventional standard medical treatment, were subsequently treated with mechanical thrombectomy using the Penumbra System®. In all cases, medical treatment including anticoagulants were continued following the procedure for a minimum period of 1 year. Results: Recanalization of the dural sinus thrombosis was achieved in all 8 cases. There were no immediate or late endovascular-related complications. One death occurred due to an unrelated medical event. At 6 months, there was notable improvement in the modified Rankin Score (mRS), with 5/8 (62%) patients achieving mRS of 2 or less. The follow-up ranged between 3 months and 26 months (mean: 14.5 months), and there were no new neurological events during the follow-up period. Conclusion: Cerebral venous sinus thrombosis is a rare but life-threatening condition that demands timely diagnosis and therapy. In cases of rapidly declining neurological status despite standard therapy with systemic anticoagulation and anti-edema measures, mechanical thrombectomy could be a lifesaving and effective option. In this study, good outcomes were observed in the majority of patients at long-term follow up. |
topic |
dural sinus thrombosis neurointervention recanalization thrombectomy |
url |
http://www.thieme-connect.de/DOI/DOI?10.4103/0971-3026.202956 |
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