FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling

FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling

<p>Abstract</p> <p>Background</p> <p>Cytoplasmic viral double-stranded RNA (dsRNA) is detected by a class of ubiquitous cytoplasmic RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation antigen-5 (MDA5), which initiate a signaling cascade vi...

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Bibliographic Details
Main Authors: Jordan Katherine C, Tupper Joan C, Handa Priya, Harlan John M
Format: Article
Language:English
Published: BMC 2011-06-01
Series:Cell Communication and Signaling
Online Access:http://www.biosignaling.com/content/9/1/16

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