Pituitary adenylate cyclase-activating polypeptide ameliorates experimental acute ileitis and extra-intestinal sequelae.

The neuropeptide Pituitary adenylate cyclase-activating polypeptide (PACAP) plays pivotal roles in immunity and inflammation. So far, potential immune-modulatory properties of PACAP have not been investigated in experimental ileitis.Mice were perorally infected with Toxoplasma (T.) gondii to induce...

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Main Authors: Markus M Heimesaat, Ildiko R Dunay, Silvia Schulze, André Fischer, Ursula Grundmann, Marie Alutis, Anja A Kühl, Andrea Tamas, Gabor Toth, Miklos P Dunay, Ulf B Göbel, Dora Reglodi, Stefan Bereswill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4169633?pdf=render