Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” Studies
There is a persistent debate on the optimal target temperature to use during cooling procedures in cardiac arrest survivors. A large randomized clinical trial (RCT) including more than 900 patients showed that targeted temperature management (TTM) at 33 °C had similar mortality and unfavorable neuro...
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doaj-831dcd037dc04a32bd75dfa7b30c4bfd2021-02-04T00:00:17ZengMDPI AGBrain Sciences2076-34252021-02-011118618610.3390/brainsci11020186Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” StudiesAndrea Minini0Filippo Annoni1Lorenzo Peluso2Elisa Gouvêa Bogossian3Jacques Creteur4Fabio Silvio Taccone5Department of Intensive Care, Erasmus Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Brussels, BelgiumDepartment of Intensive Care, Erasmus Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Brussels, BelgiumDepartment of Intensive Care, Erasmus Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Brussels, BelgiumDepartment of Intensive Care, Erasmus Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Brussels, BelgiumDepartment of Intensive Care, Erasmus Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Brussels, BelgiumDepartment of Intensive Care, Erasmus Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Brussels, BelgiumThere is a persistent debate on the optimal target temperature to use during cooling procedures in cardiac arrest survivors. A large randomized clinical trial (RCT) including more than 900 patients showed that targeted temperature management (TTM) at 33 °C had similar mortality and unfavorable neurological outcome (UO) rates as TTM at 36 °C in out-of-hospital cardiac arrest patients with any initial rhythm. Since then, several observational studies have been published on the effects of changes in target temperature (i.e., from 33 to 36 °C) on patients’ outcome. We performed a systematic literature search from 1 January 2014 to 4 December 2020 and identified nine retrospective studies (very low levels of certainty; high risk of bias), including 3799 patients, that evaluated TTM at 33 °C vs. TTM at 36 °C on the occurrence of UO (n = seven studies) and mortality (n = nine studies). TTM at 33 °C was associated with a lower risk of UO when studies assessing neurological outcome with the Cerebral Performance Categories were analyzed (OR 0.80 [95% CIs 0.65–0.99]; <i>p</i> = 0.04). No differences in mortality were observed within the two TTM strategies. These results suggest that an inappropriate translation of TTM protocols from large well-conducted randomized trials into clinical management may result in unexpected effects on patients’ outcome. As for all newly commercialized drugs, epidemiological studies and surveillance programs with an adequate follow-up on large databases are necessary to understand how RCTs are implemented into medical practice.https://www.mdpi.com/2076-3425/11/2/186targeted temperature managementdosecardiac arrest33 °C36 °Coutcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Minini Filippo Annoni Lorenzo Peluso Elisa Gouvêa Bogossian Jacques Creteur Fabio Silvio Taccone |
spellingShingle |
Andrea Minini Filippo Annoni Lorenzo Peluso Elisa Gouvêa Bogossian Jacques Creteur Fabio Silvio Taccone Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” Studies Brain Sciences targeted temperature management dose cardiac arrest 33 °C 36 °C outcome |
author_facet |
Andrea Minini Filippo Annoni Lorenzo Peluso Elisa Gouvêa Bogossian Jacques Creteur Fabio Silvio Taccone |
author_sort |
Andrea Minini |
title |
Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” Studies |
title_short |
Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” Studies |
title_full |
Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” Studies |
title_fullStr |
Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” Studies |
title_full_unstemmed |
Which Target Temperature for Post-Anoxic Brain Injury? A Systematic Review from “Real Life” Studies |
title_sort |
which target temperature for post-anoxic brain injury? a systematic review from “real life” studies |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-02-01 |
description |
There is a persistent debate on the optimal target temperature to use during cooling procedures in cardiac arrest survivors. A large randomized clinical trial (RCT) including more than 900 patients showed that targeted temperature management (TTM) at 33 °C had similar mortality and unfavorable neurological outcome (UO) rates as TTM at 36 °C in out-of-hospital cardiac arrest patients with any initial rhythm. Since then, several observational studies have been published on the effects of changes in target temperature (i.e., from 33 to 36 °C) on patients’ outcome. We performed a systematic literature search from 1 January 2014 to 4 December 2020 and identified nine retrospective studies (very low levels of certainty; high risk of bias), including 3799 patients, that evaluated TTM at 33 °C vs. TTM at 36 °C on the occurrence of UO (n = seven studies) and mortality (n = nine studies). TTM at 33 °C was associated with a lower risk of UO when studies assessing neurological outcome with the Cerebral Performance Categories were analyzed (OR 0.80 [95% CIs 0.65–0.99]; <i>p</i> = 0.04). No differences in mortality were observed within the two TTM strategies. These results suggest that an inappropriate translation of TTM protocols from large well-conducted randomized trials into clinical management may result in unexpected effects on patients’ outcome. As for all newly commercialized drugs, epidemiological studies and surveillance programs with an adequate follow-up on large databases are necessary to understand how RCTs are implemented into medical practice. |
topic |
targeted temperature management dose cardiac arrest 33 °C 36 °C outcome |
url |
https://www.mdpi.com/2076-3425/11/2/186 |
work_keys_str_mv |
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