Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma

Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma

Paraneoplastic syndromes are commonly encountered in renal cell carcinoma, but neurological manifestations are rare. Herein we report a case of a patient with locally advanced renal cell carcinoma who presented with Parkinson-like symptoms which prohibited surgery due to poor performance status. How...

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Bibliographic Details
Main Authors: Naveed Ali, Alexander Kutikov, Daniel M. Geynisman
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Urology Case Reports
Subjects:
Renal cell carcinoma
Paraneoplastic syndrome
Tyrosine kinase inhibitor therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2214442017301109
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spelling doaj-831e479e9b4a467397a3fc3983ace9c02020-11-24T20:54:58ZengElsevierUrology Case Reports2214-44202017-09-0114C182010.1016/j.eucr.2017.05.007Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell CarcinomaNaveed Ali0Alexander Kutikov1Daniel M. Geynisman2Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USADepartment of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USADepartment of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USAParaneoplastic syndromes are commonly encountered in renal cell carcinoma, but neurological manifestations are rare. Herein we report a case of a patient with locally advanced renal cell carcinoma who presented with Parkinson-like symptoms which prohibited surgery due to poor performance status. However, a significant improvement was noted after tyrosine kinase inhibitor therapy, allowing the patient to proceed to curative surgery.http://www.sciencedirect.com/science/article/pii/S2214442017301109Renal cell carcinomaParaneoplastic syndromeTyrosine kinase inhibitor therapy
collection DOAJ
language English
format Article
sources DOAJ
author Naveed Ali
Alexander Kutikov
Daniel M. Geynisman
spellingShingle Naveed Ali
Alexander Kutikov
Daniel M. Geynisman
Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
Urology Case Reports
Renal cell carcinoma
Paraneoplastic syndrome
Tyrosine kinase inhibitor therapy
author_facet Naveed Ali
Alexander Kutikov
Daniel M. Geynisman
author_sort Naveed Ali
title Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_short Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_full Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_fullStr Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_full_unstemmed Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_sort resolution of a debilitating paraneoplastic parkinson-like neurological syndrome following tyrosine inhibitor therapy and consolidative nephrectomy in a patient with advanced clear cell renal cell carcinoma
publisher Elsevier
series Urology Case Reports
issn 2214-4420
publishDate 2017-09-01
description Paraneoplastic syndromes are commonly encountered in renal cell carcinoma, but neurological manifestations are rare. Herein we report a case of a patient with locally advanced renal cell carcinoma who presented with Parkinson-like symptoms which prohibited surgery due to poor performance status. However, a significant improvement was noted after tyrosine kinase inhibitor therapy, allowing the patient to proceed to curative surgery.
topic Renal cell carcinoma
Paraneoplastic syndrome
Tyrosine kinase inhibitor therapy
url http://www.sciencedirect.com/science/article/pii/S2214442017301109
work_keys_str_mv AT naveedali resolutionofadebilitatingparaneoplasticparkinsonlikeneurologicalsyndromefollowingtyrosineinhibitortherapyandconsolidativenephrectomyinapatientwithadvancedclearcellrenalcellcarcinoma
AT alexanderkutikov resolutionofadebilitatingparaneoplasticparkinsonlikeneurologicalsyndromefollowingtyrosineinhibitortherapyandconsolidativenephrectomyinapatientwithadvancedclearcellrenalcellcarcinoma
AT danielmgeynisman resolutionofadebilitatingparaneoplasticparkinsonlikeneurologicalsyndromefollowingtyrosineinhibitortherapyandconsolidativenephrectomyinapatientwithadvancedclearcellrenalcellcarcinoma
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