miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint
Resistance to chemotherapy occurs in many ovarian cancer cases. Here, the authors show that mir-424(322) expression restores the sensitivity of ovarian cancer cells to chemotherapy by blocking the PD-L1 immune checkpoint, and find that combining immunotherapy and chemotherapy has a synergistic effec...
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Bibliographic Details
| Main Authors: |
Shaohua Xu,
Zhen Tao,
Bo Hai,
Huagen Liang,
Ying Shi,
Tao Wang,
Wen Song,
Yong Chen,
Jun OuYang,
Jinhong Chen,
Fanfei Kong,
Yishan Dong,
Shi-Wen Jiang,
Weiyong Li,
Ping Wang,
Zhiyong Yuan,
Xiaoping Wan,
Chenguang Wang,
Wencheng Li,
Xiaoping Zhang,
Ke Chen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms11406
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