Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies
Coronavirus Disease 2019 (COVID‑19) is caused by novel Severe Acute Respiratory Syndrome Coronavirus‑2 (SARS‑CoV‑2). The disease was first reported from Wuhan, China, in December 2019 and since then it continues to spread worldwide. Although, there are rapidly increasing number of studies on epide...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14675/47604_CE[Ra1]_F[SK]_PF1(AKA_SHU)_PN(KM).pdf |
| Summary: | Coronavirus Disease 2019 (COVID‑19) is caused by novel Severe Acute Respiratory Syndrome Coronavirus‑2 (SARS‑CoV‑2). The
disease was first reported from Wuhan, China, in December 2019 and since then it continues to spread worldwide. Although,
there are rapidly increasing number of studies on epidemiologic characteristics and clinical aspects of COVID-19, its pathology
still remains a largely unexplored territory, mainly due to limited autopsy studies. Autopsy studies are essential to demonstrate
the spectrum of COVID-19-associated organ changes. This article reviews and highlights the important histopathological findings
observed in different organ systems as evident from various published and anecdotal reports from across the world. Major
histopathological findings in the lungs include different stages of Diffuse Alveolar Damage (DAD) and microthrombi along with
variable degree of inflammation. Microscopic analysis of renal parenchyma may show acute tubular injury and fibrin thrombi in the
glomerular capillaries. Heart, liver and brain show no significant inflammatory changes. |
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| ISSN: | 2249-782X 0973-709X |