Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies
Coronavirus Disease 2019 (COVID‑19) is caused by novel Severe Acute Respiratory Syndrome Coronavirus‑2 (SARS‑CoV‑2). The disease was first reported from Wuhan, China, in December 2019 and since then it continues to spread worldwide. Although, there are rapidly increasing number of studies on epide...
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doaj-8339445869ca4896bc6995b7dcce33232021-06-14T08:28:15ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-04-01154EE01EE0510.7860/JCDR/2021/47604.14675Pathology of COVID-19: A Review of Emerging Evidences from Autopsy StudiesSeetu Palo0Debadutta Mishra1Assistant Professor, Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bibinagar, Hyderabad Metropolitan Region, India.Associate Professor, Department of Microbiology, Andaman and Nicobar Islands institute of medical sciences, Port Blair, Andaman and Nicobar Islands, India.Coronavirus Disease 2019 (COVID‑19) is caused by novel Severe Acute Respiratory Syndrome Coronavirus‑2 (SARS‑CoV‑2). The disease was first reported from Wuhan, China, in December 2019 and since then it continues to spread worldwide. Although, there are rapidly increasing number of studies on epidemiologic characteristics and clinical aspects of COVID-19, its pathology still remains a largely unexplored territory, mainly due to limited autopsy studies. Autopsy studies are essential to demonstrate the spectrum of COVID-19-associated organ changes. This article reviews and highlights the important histopathological findings observed in different organ systems as evident from various published and anecdotal reports from across the world. Major histopathological findings in the lungs include different stages of Diffuse Alveolar Damage (DAD) and microthrombi along with variable degree of inflammation. Microscopic analysis of renal parenchyma may show acute tubular injury and fibrin thrombi in the glomerular capillaries. Heart, liver and brain show no significant inflammatory changes.https://www.jcdr.net/articles/PDF/14675/47604_CE[Ra1]_F[SK]_PF1(AKA_SHU)_PN(KM).pdfacute tubular injurycoronavirus disease 2019diffuse alveolar damagemicrothrombisevere acute respiratory syndrome coronavirus-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seetu Palo Debadutta Mishra |
spellingShingle |
Seetu Palo Debadutta Mishra Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies Journal of Clinical and Diagnostic Research acute tubular injury coronavirus disease 2019 diffuse alveolar damage microthrombi severe acute respiratory syndrome coronavirus-2 |
author_facet |
Seetu Palo Debadutta Mishra |
author_sort |
Seetu Palo |
title |
Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies |
title_short |
Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies |
title_full |
Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies |
title_fullStr |
Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies |
title_full_unstemmed |
Pathology of COVID-19: A Review of Emerging Evidences from Autopsy Studies |
title_sort |
pathology of covid-19: a review of emerging evidences from autopsy studies |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2021-04-01 |
description |
Coronavirus Disease 2019 (COVID‑19) is caused by novel Severe Acute Respiratory Syndrome Coronavirus‑2 (SARS‑CoV‑2). The
disease was first reported from Wuhan, China, in December 2019 and since then it continues to spread worldwide. Although,
there are rapidly increasing number of studies on epidemiologic characteristics and clinical aspects of COVID-19, its pathology
still remains a largely unexplored territory, mainly due to limited autopsy studies. Autopsy studies are essential to demonstrate
the spectrum of COVID-19-associated organ changes. This article reviews and highlights the important histopathological findings
observed in different organ systems as evident from various published and anecdotal reports from across the world. Major
histopathological findings in the lungs include different stages of Diffuse Alveolar Damage (DAD) and microthrombi along with
variable degree of inflammation. Microscopic analysis of renal parenchyma may show acute tubular injury and fibrin thrombi in the
glomerular capillaries. Heart, liver and brain show no significant inflammatory changes. |
topic |
acute tubular injury coronavirus disease 2019 diffuse alveolar damage microthrombi severe acute respiratory syndrome coronavirus-2 |
url |
https://www.jcdr.net/articles/PDF/14675/47604_CE[Ra1]_F[SK]_PF1(AKA_SHU)_PN(KM).pdf |
work_keys_str_mv |
AT seetupalo pathologyofcovid19areviewofemergingevidencesfromautopsystudies AT debaduttamishra pathologyofcovid19areviewofemergingevidencesfromautopsystudies |
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1721378596949327872 |